Implementation Research: Using Science to Guide Implementation of Evidence-Based Practices Brian S. Mittman, PhD Director, VA Center for Implementation.

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Presentation transcript:

Implementation Research: Using Science to Guide Implementation of Evidence-Based Practices Brian S. Mittman, PhD Director, VA Center for Implementation Practice and Research Support November 4, 2010 Quality Enhancement Research Initiative

Increased investment and activity in implementation research are critical to achievement of key societal goals in health and health care

Part 1: Introduction: Policy/practice foundations of implementation and implementation research Part 2: Frameworks for implementation research Part 3: Implementation research resources Outline

The need to accelerate implementation in health: Two streams of policy concern Stream 1 -- translational roadblocks; implementation gap barriers to rapid, efficient progression of innovations from basic science to clinical application to routine use Stream 2 -- quality chasm gaps in the quality, safety, equity, efficiency, timeliness and patient-centeredness of health care delivery

Stream 1: Translational roadblocks and inefficiency in health research Basic / Lab Research Clinical Research Improved Health Basic / Lab Research Clinical Research Improved Health Type 1 Translation Type 2 Translation

The Implementation Gap (second translational roadblock) NIH recognition NIH Roadmap (June 2003+) and CTSA program

Investing in discovery/development vs. fidelity

Stream #2: the “Quality Chasm” Institute of Medicine (1999, 2001) US and international quality measurement studies

Quality comparisons: VA vs. other US

Implementation research definition, goals Implementation research is the scientific study of methods to promote the systematic uptake of research findings and other evidence-based practices into routine practice, and, hence, to improve the quality and effectiveness of health services. It includes the study of influences on healthcare professional and organizational behavior. 1. Develop and evaluate implementation programs 2. Study implementation processes, barriers, facilitators 3. Develop, test and refine implementation theories and hypotheses; methods and measures

Key terms and concepts diffusion vs. dissemination vs. implementation innovation, best practice, evidence-based practice clinical/health services intervention, implementation intervention, implementation program or strategy quality improvement (QI) context

Implementation research vs. quality improvement research Generally speaking… implementation research studies processes and strategies for increasing adoption, use of innovative, effective practices and research findings, whereas quality improvement research studies approaches for addressing quality problems (often – but not always – via implementation of effective, innovative practices) Both fields encompass theory, research, policy and practice in organizational and professional behavior and behavior change

Part 1: Introduction: Policy/practice foundations of implementation and implementation research Part 2: Frameworks for implementation research Part 3: Implementation research resources Outline

1. Refined research-implementation pipeline: Implementation research and clinical research Translational Pre-Clinical Research Basic Science Improved Health Processes, Outcomes Implemen- tation Research Clinical Health Behavior Basic/Lab Science Clinical Science Health Services Research Health Services Health Behavior/ Promotion Research Effective -ness Studies

2. The Classic Six-Step QUERI Process 1.Identify high risk/high burden conditions 2.Identify best practices 3.Define existing practice patterns in VA and variations from best practices 4.Identify (or develop) and implement programs to promote best practices 5.Document outcome and system improvements 6.Document improvements in health related quality of life

VA QUERI research-implementation pipeline: Pre-implementation and implementation studies Implementation Trials Clinical Health Behavior Health Services Effectiveness Studies Document and diagnose gaps Practice Guidelines Observational studies of implementation Efficacy Studies Implementation research

Preparing for implementation: Observational pre-trial research Step O: Observational Studies of Implementation natural experiments (policy initiatives, diffusion of innovation studies) focus on contextual influences, implementation (practice change) mechanisms, processes emphasize external over internal validity measure implementation (fidelity) and its influences within hybrid effectiveness-implementation studies

Preparing for implementation: Observational pre-implementation research Step 3: Measure and Diagnose Quality/Performance Gaps 3A. measure existing practice patterns and outcomes and identify variations from evidence-based practices and benchmark outcomes (quality, outcome and performance gaps) 3B. identify determinants of current practices 3C. diagnose quality gaps 3D. identify barriers and facilitators to improvement

3. QUERI Four-Phase Implementation Research Framework Phase 1 Pilot Projects Phase 1 Pilot Projects Phase 2 Small-Scale Efficacy Trials Phase 2 Small-Scale Efficacy Trials Phase 3 Large-Scale Effectiveness Trials Phase 3 Large-Scale Effectiveness Trials Phase 4 “Post-Marketing” Monitoring, Refinement Implementation Trials Clinical Health Behavior Health Services Effectiveness Studies Practice Guidelines Efficacy Studies Document and diagnose gaps Observational studies of implementation Implementation research

3. QUERI Four-Phase Implementation Research Framework PhaseStudy TypeForm of Evaluation Pre-trialProgramConceptual design of implementation program and underlying design (logic) model from theory, prior empirical research Phase 1Pilot /Pilot test, assess feasibility, formative evaluation and refinement, Formativedevelop intervention/evaluation protocols Phase 2EfficacySmall-scale rigorous trial in controlled settings with ongoing intervention support; emphasis on internal validity Phase 3EffectivenessLarge-scale rigorous trial under routine conditions in varied settings; emphasis on external validity Phase 4Monitoring Ongoing monitoring and feedback

4. QUERI SDP Template: Section D D. Design and methods (continued) –Evaluation details: impact evaluation outcomes (patient, system outcomes) contextual factors –Evaluation details: formative/process evaluation describe mechanisms of impact analysis plans (to explain mechanisms and variations) –Evaluation details: other sustainability, spread/scale-up potential and pathway economics

Part 1: Introduction: Policy/practice foundations of implementation and implementation research Part 2: Frameworks for implementation research Part 3: Implementation research resources Outline

National, international resources NIH Conference on the Science of Dissemination and Implementation (2007, 2009, 2010, 2011) NIH PARs, study section NIH- and AHRQ-funded training programs Journals: Implementation Science, Translational Behavioral Medicine, special issues of general and specialty journals CTSAs (selected) PBRNs VA QUERI Knowledge Translation Canada (network), other CIHR programs

Local resources Medical schools: GIM, Preventive Medicine, Family Medicine Public health schools: health services, healthcare management, community health departments Nursing schools: research utilization programs Main campus: management schools, education schools, public policy schools, psychology departments (and sociology, anthropology, political science, economics)

Critical resources Practice-based research network or related lab Social/behavioral science expertise Management, leadership skills (training, aptitude) Local, regional and national policy/practice engagement and contributions -- and academic recognition and credit