Hyaluronic Acid Hydrogel Films October 27, 2008 Scott Zawko – Post-doctoral Researcher (Presentation to Dr Raymond Grill)

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Presentation transcript:

Hyaluronic Acid Hydrogel Films October 27, 2008 Scott Zawko – Post-doctoral Researcher (Presentation to Dr Raymond Grill)

Isolation of Hyaluronic Acid - Hydrophilic -High Molecular Weight -Viscoelastic Solutions - Anionic Molecular Properties HA isolated from cattle eyeballs

Other Applications - Adhesion Barrier (Seprafilm ® ) - Dermal Filler (Restylane ® ) Hyaluronic Acid Materials Images taken from healon.com and synvisc.com Vitreous substitute (Healon ® ) Viscosupplementation (Synvisc ® )

+ GMHA Triethylamine Water/Acetone (50/50) Synthesis of GMHA Hyaluronic Acid (HA) Glycidyl Methacrylate (GM) The average degree of substitution of GMHA is 0.32 (i.e., 32 out of every 100 disaccharides bears a methacrylate group).

365 nm UV Irgacure 2959 Photocrosslinked GMHA Hydrogels GMHA Bulk HydrogelsGMHA Hydrogel Film photocrosslink

GMHA Bulk Hydrogel Biocompatibility Leach, J.B. et al Biotechnol. Bioeng. EXPERIMENTAL: Hydrogels were subcutaneously implanted in rat and explanted at 2 weeks. The implanted hydrogels had been placed in plastic devices that allowed them to be easily located for explantation. RESULTS: Inflammation was minimal; hydrogels were partially degraded; endothelial cell infiltration into GMHA hydrogels was not statistically different from fibrin gels.

Features of GMHA Hydrogel Films Optically Transparent Low Swelling (66% water) Non Cell Adhesive Zawko, S.A. Dissertation, UT Austin

GMHA hydrogel films as a surgical nerve wrap - Prevent cellular infiltration - Permit diffusion of oxygen, salts, metabolites - Biodegradable - Isolate nerve gap

Scale-up of crystal templated HA hydrogels 1000  m Scale bars are 10  m Zawko, S.A. Dissertation, UT Austin

Schmidt Lab Publications with GMHA Hydrogels 1. Chemistry and material characterization 2. Peptide functionalization 3. Protein release Leach, J.B. et al Biotechnol. Bioeng. Leach, J.B. et al J. Biomed. Mater. Res. Leach, J.B. et al Biomaterials 4. Drug release Zawko, S.A. et al. (In press) J. Biomed. Mater. Res. 5. Patterned swelling Zawko, S.A. et al. (In press) Acta Biomaterialia 1. Synthesis and characterization Zawko, S.A. Dissertation, UT Austin GMHA Bulk Hydrogels GMHA Hydrogel Films 2. Crystal templating Zawko, S.A. Dissertation, UT Austin (Manuscript in preparation)