B. Keith English, M.D. Chair, Pediatrics & Human Development Departmental Update B. Keith English, M.D. Chair, Pediatrics & Human Development

Multi-Campus Model for Pediatrics in CHM Upper Peninsula: Marquette General Hospital Midland Regional: MidMichigan Health (Midland, Alma, Gladwin, Clare) Flint: Hurley Children’s Hospital Upper Peninsula Region Hospital Partners = Student Clinical Education Sites Grand Rapids : HDVCH Lansing: Sparrow Children’s Center Traverse City: Munson Medical Center Traverse City Midland Region Grand Rapids Flint Lansing

Pediatrics and Human Development APR: Timetable Self-study to be completed by February 1, 2015 Report to Dean and then Provost in April, 2015 Great opportunity for strategic planning for Pediatrics

The Six Key Questions for the APR What do we do? Why do we do it? How well do we do it and who thinks so? What difference would it make whether we did it or not? Given our present status, how do we intend to change in ways that help us advance? How will we evaluate our future progress and successes?

New Faculty Andre Bachmann, PhD, tenured Professor, Grand Rapids campus, started 1/5/15 Aghiad Chamdin, M.D., Assistant Professor, Pediatric Hematology-Oncology, starts 2/1/15 (4/1/15) Rebecca Schein, M.D., Assistant Professor, Pediatric Infectious Diseases, starts 3/15/15

Faculty Recruitment Plans Posted positions in Pediatric Pulmonology and Pediatric Hematology-Oncology Plans to post positions in Academic General Pediatrics (2), Neonatology, Developmental-Behavioral Pediatrics (DBP) and Child Psychology or Speech Language Pathology

Faculty Recruitment Plans DBP and PhD (child psychology or speech language pathology) recruits part of MDCH-funded development of autism services in Lansing Plans to develop an “Approved Autism Evaluation Center” (AAEC) in partnership with Wardcliff Abilities Center (Jane Turner and Kathryn Larson are spearheading this effort)

Faculty Recruitment Plans Recruitment for three investigator positions in autism-related research underway Plans to recruit at least three individual investigators in pediatric neurosciences in Grand Rapids in partnership with pediatric neurology expansion at HDVCH

Academic Competitiveness Funds MSU Plans to hire 100 new STEM faculty in next couple of years Funding from Office of the Provost and OVPRGS Proposals solicited from Departments and Colleges in November; additional discussions underway

Academic Competitiveness Funds “Precision Pediatrics” concept has been well-received by MSU leadership Partnership with Rick Leach in Ob-Gyn in maternal-infant health proposal Partnership with George Mias, Rick Neubig, others, for “Precision Pediatrics” proposal

Precision Pediatrics at MSU B. Keith English, M.D. Chair, Pediatrics & Human Development

Why “Precision” Pediatrics? Personalized, individualized, or precision pediatrics? For some, “personalized medicine” denotes the creation and use of unique therapies for every patient, whereas “precision medicine” refers to the “tailoring of medical treatment to the individualized characteristics of each patient” (National Research Council, 2011)

Fit with Grand Initiatives and NIH Funding Priorities Fit with NICHD Funding Priorities for the next decade: “Catalog and identify interrelated environmental and genetics factors that are key to .. health” Focus areas include developmental origins of health and disease & behavior and cognition (interventions for autism and pharmaceutics for brain recovery) Fit with the NIH/DARPA/NSF “Brain Initiative” Fit with with National Human Genome Research Institute (NHGRI) funding priorities

Fit with MSU ACF Principles Enhancing competitiveness and excellence of tenured MSU faculty (1), improved NIH funding (4), and align-ment with Grand Challenges & funding priorities (3) Enhancing status of MSU investigators to exceed that of our aspirational peers (2) and be on par with leading centers (“precision medicine” being embraced by UCSF, UCLA, Stanford, Duke, Harvard) Great potential for stronger international collaboration in pediatrics (5) (e.g., Malawi, Brasil) and for expanding MSU institutional diversity (6), in bringing “precision pediatrics” to populations of children – in Michigan and around the world

Fit with Multi-campus model for CHM Pediatrics Fit with expansion of pediatric neurology, epilepsy and neuroscience in Grand Rapids ( & epigenetics at VARI) Fit with expanded programs in autism-related research in Pediatrics in East Lansing Fit with public health expansion in Flint (e.g., neuroscience of sleep) and CHM investigators in Traverse City (autism), Saginaw, Marquette

How To Build “Precision Pediatrics” (1) Recruit Leading Omics/Big Data Scientists (2) Recruit Leading Physician-Scientists whose focus is on genetics/epigenetics of major medical conditions in children (e.g., autism/NDDs, asthma, childhood cancers) (3) Recruit Leading Health Services researchers whose aim is to bring Precision Pediatrics to populations of children