Chemical Science and Technology Laboratory Overview Process Analytical Technologies Subcommittee Meeting June 12 – 13, 2002 Rockville, MD Chemical Science and Technology Laboratory James Whetstone, Chief Process Measurements Division

Chemical Science and Technology Laboratory NIST Vision … NIST Vision … is to be the global leader in measurement and enabling technology, delivering outstanding value to the nation. NIST Mission … NIST Mission … is to develop and promote measurement, standards, and technology to enhance productivity, facilitate trade, and improve the quality of life. Core Values: People … we respect, value and support each other in all our activities. Integrity … we are objective, ethical, and honest. Customer focus …we anticipate the needs of our customers and are committed to meeting or exceeding their expectations. Excellence … we expect world-class performance and continuous improvement in all we do. NIST … enabling a better future

Chemical Science and Technology Laboratory Improving the Economy: Refrigerants Automobiles …working with U.S. Industry Electric Power Information & Semiconductor Technology Cell Phones Improving the Quality of Life: Medical Tests Mammography Cancer Treatment Smoke Detectors Body Armor Dentistry

Chemical Science and Technology Laboratory National Institute of Standards and Technology Electronics and Electrical Engineering Laboratory Wm. Anderson Chemical Science and Technology Laboratory Hratch Semerjian Materials Science and Engineering Laboratory Leslie Smith Information Technology Laboratory Susan Zevin (Act.) Manufacturing Engineering Laboratory Dale Hall Physics Laboratory Katharine Gebbie Building and Fire Research Laboratory Jack Snell Boulder Laboratories Vacant Director Arden Bement Deputy Director Karen Brown National Quality Program National Quality Program Harry Hertz Technology Services Richard Kayser Advanced Technology Program Advanced Technology Program Marc Stanley (Act.) Manufacturing Extension Partnership Manufacturing Extension Partnership Kevin Carr Jorge Urrutia Director for Administration

Chemical Science and Technology Laboratory National Institute of Standards and Technology Electronics and Electrical Engineering Laboratory Wm. Anderson Chemical Science and Technology Laboratory Hratch Semerjian Materials Science and Engineering Laboratory Leslie Smith Information Technology Laboratory Susan Zevin (Act.) Manufacturing Engineering Laboratory Dale Hall Physics Laboratory Katharine Gebbie Building and Fire Research Laboratory Jack Snell Boulder Laboratories Vacant Director Arden Bement Deputy Director Karen Brown National Quality Program National Quality Program Harry Hertz Technology Services Richard Kayser Advanced Technology Program Advanced Technology Program Marc Stanley (Act.) Manufacturing Extension Partnership Manufacturing Extension Partnership Kevin Carr Jorge Urrutia Director for Administration

Chemical Science and Technology Laboratory CSTL Mission As the Nation’s Reference Laboratory, CSTL’s Mission is to provide the chemical measurement infrastructure to: enhance U.S. industry's productivity and competitiveness; assure equity in trade; and improve public health, safety, and environmental quality. CSTL Vision A world class research laboratory recognized by the Nation as the primary resource for chemical, biomolecular, and chemical engineering measurements, data, models, and reference standards required to enhance U.S. industrial competitiveness in the world market.

Chemical Science and Technology Laboratory CSTL Goals Measurement Standards Establish CSTL as the pinnacle of the national traceability and international comparability structure for measurements in chemistry, chemical engineering and biotechnology, and provide the fundamental basis of the nation’s measurement system Chemical and Process Information Assure that U.S. industry has access to accurate and reliable data and predictive models to determine the chemical and physical properties of materials and processes Measurement Science Anticipate and address next generation measurement needs of the nation, by performing cutting-edge research

Chemical Science and Technology Laboratory CHEMICAL SCIENCE AND TECHNOLOGY LABORATORY Hratch G. Semerjian, Director William F. Koch, Deputy Director Atmospheric Chemistry Microanalysis Research Surface & Interface Research Analytical Microscopy Surface & Microanalysis Science R. Cavanagh, Chief Surface & Microanalysis Science R. Cavanagh, Chief Experimental Kinetics & Thermodynamics Chemical Reference Data & Modeling Computational Chemistry Experimental Properties of Fluids Theory & Modeling of Fluids Cryogenic Tech. Physical & Chemical Properties M. Haynes, Chief Physical & Chemical Properties M. Haynes, Chief Spectrochemical Methods Organic Analytical Methods Gas Metrology & Classical Methods Molecular Spectroscopy & Microfluidic Methods Nuclear Methods Analytical Chemistry W. May, Chief Analytical Chemistry W. May, Chief Fluid Flow Fluid Science Process Sensing Thermometry Pressure and Vacuum Thermal and Reactive Processes Process Measurements J. Whetstone, Chief Process Measurements J. Whetstone, Chief Biotechnology V. Vilker, Act. Chief Biotechnology V. Vilker, Act. Chief DNA Technologies Bioprocess Engineering Structural Biology Biomolecular Materials Organized by Discipline …

Chemical Science and Technology Laboratory CSTL Programs Transportation Energy Systems Biotechnology Nanotechnology Healthcare Environmental Technologies Microelectronics Data and Informatics Biomaterials Forensics International Measurement Standards Chemical and Allied Products Industrial and Analytical Instrument Services Food and Nutrition … Focused by Customer-Driven Programs

Chemical Science and Technology Laboratory CSTL Facilities CARB ACSL NIST Boulder NIST Charleston

Chemical Science and Technology Laboratory CSTL Activities Impacting Process Analytical & Process Measurements Standard Reference Materials  Raman Spectroscopy – Intensity Standards  Spectrophotometry – Optical Absorbance Standards Reference Data  NIR Spectral Data Directly Tied to U.S. National Gas Concentration Standards  Mass Spectrometric Database and Spectral Diagnostic Tools  Protein Data Bank – Biomolecular Structures Instrument Calibration Services  Temperature, Pressure, Vacuum, Humidity, Flowrate, and Liquid Volume and Density

Chemical Science and Technology Laboratory Intensity Standards for Raman Spectroscopy : Objective: Provide (first-ever) standard for intensity and frequency shift of Raman signals Customers: Instrument mfrs., chemical processing, DoD, DoE, pharmaceutical Industry Form: Uranyl Silicate Glass standard cuvette geometry Status: Evaluated prototype standard with ASTM Committee First SRM (785 nm) by 9/2002 Next Steps: Develop additional SRMs (488, 514.5, 533, 633, 1064 nm) nm Broadband fluorescence from uranyl silicate glass Impacts: These standards will transform Raman from qualitative lab diagnostic into process instrumentation, allowing quantitative comparison of instrument response in differing locations and installations

Chemical Science and Technology Laboratory NIST Mission … NIST Mission … is to develop and promote measurement, standards, and technology to enhance productivity, facilitate trade, and improve the quality of life. –Assist Industry and Other Government Agencies to improve measurements, measurement standards, technologies, and practices. IFPAC 2003 – January 2003 An opportunity to interact with Process Analytical Specialists in a Range of Industrial Applications