Myoid Thymoma in F-344 Rats

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Presentation transcript:

Myoid Thymoma in F-344 Rats Neil Allison, DVM Diplomate ACVP Experimental Pathology Laboratories, Inc Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Signalment Rat, F-344 Female 1.5 year-old Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

History National Toxicology Program (NTP) chronic carcinogenesis study Thin, ataxic and breathing abnormally on day 526 of the study Euthanasia Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Necropsy Findings Cranial mediastinal mass Discrete, oval, mottled 40 x 32 x 25 mm Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Desmin Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Cytokeratin Note cytoplasmic weak cytoplasmic staining of mesenchymal cell Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Diagnosis Myoid thymoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Discussion Reviewed all thymomas in NTP Data from 1972-2003 Approximately 189,500 F344 rats 4/244 thymomas with myoid component One myoid thymoma after 2003 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Discussion Benign or malignant? Gross = Huge and discrete mass No invasion of viscera, diaphragm or body wall No Metastasis Cytology = Malignant Behavior = Benign Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Discussion Other Names Carcinosarcoma Sarcomatoid carcinoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Acknowledgement Julie Foley Natasha Clayton Maureen Puccini Emily Singletary David Sabio Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

References 1. Snover MS , Levine GD, Rosai J: Thymic carcinoma. Five distinct histological variants. Am j Surg Pathol 6:451-470, 1982 2. Rosai J, Sobin LH: Histological typing of tumours of the thymus. In: World Health Organisation, International Histological Classification of Tumours, 2nd ed., pp.1-58. Springer, Berlin, Germany, 1999 3. Henry K: An unusual tumour with a striated muscle (myoid) component (with a brief review of the literature on myoid cells). Brit J Dis Chest 66:291-299, 1972 4. Murakami S, Shamoto M, Miura K, Takeuchi J: A thymic tumor with massive proliferation of myoid cells. Acta Pathol Jpn 34:1375-1383, 1984 5. Pearse G: Histopathology of the thymus. Toxicol Pathol 34:515-547, 2006 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only