H+H+ 1) Formazione dell’acetil-CoA + H + Decarbossilazione ossidativa.

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H+H+ 1) Formazione dell’acetil-CoA + H + Decarbossilazione ossidativa

Ossalacetato + acetilCoA + H 2 O  Citrato + HSCoA Citrato sintetasi Citrato  Isocitrato Aconitasi Isocitrato  Chetoglutarato + CO 2 + NADH + + H + Isocitrato deidrogenasi Chetoglutar.  SuccinilCoA + CO 2 + NADH + + H + Chetoglutarato deidrogenasi SuccinilCoA  Succinato +GTP + HSCoA Succinil-CoA sintetasi Succinato  Fumarato + FADH 2 Succinato deidrogenasi Fumarato + H 2 O  Malato Fumarasi Malato  Ossalacetato + NADH + + H + Malato deidrogenasi Malato deidrogenasi

 2Acetil-CoA  4CO 2 + 6NADH + 6H +, 2FADH 2 + 2CoA + 2ATP (GTP)  1 Glucosio  2 Piruvati + 2NADH + 2H + + 2ATP 2Piruvati + 2 CoA  2Acetil-CoA + 2CO 2 + 2NADH  1 Glucosio  6CO NADH + 10H + + 2FADH 2 +2CoA +2ATP (GTP)

10NADH + 10H + + 2FADH O 2  6H 2 O C 6 H 12 O O 2  6CO 2 +6H 2 O

 Ogni NADH che si scarica nella catena respiratoria è in grado di caricare 3 ATP  Ogni FADH2 che si scarica nella catena respiratoria è in grado di caricare 2 ATP  10 NADH  30 ATP  2 FADH 2  4 ATP  Totale catena respiratoria  34  Glicolisi  2ATP  Totale Metabolismo del glucosio  36 ATP  1ATP  circa 80 Kjoule di energia  36ATP  2879 Kj