Chapter 6 Essential Concepts in Molecular Pathology Companion site for Molecular Pathology Author: William B. Coleman and Gregory J. Tsongalis

Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 2 FIGURE 6.1 Human Genome Project timeline. The vertical timeline emphasizes the major years of the Human Genome Project (HGP) boxed in green with a summary of what occurred in that year to the right of the date.

Companion site for Molecular Pathology Copyright © 2009 by Academic Press. All rights reserved. 3 FIGURE 6.2 DNA rearrangements. Structural variations in the human genome result from rearrangements of DNA ranging from gross changes to single nucleotide alterations. The letters are used to depict nucleotides in a DNA sequence and lines are used to depict a gene. Each DNA rearrangement is outlined by a red box. The red arrow represents a nucleotide deletion.