SIMSAM EARLY LIFE Interdisciplinary research on early life exposure and health Coordinator: Anna Rignell-Hydbom Co-coordinator Jonas Björk Division of Occupational and Environmental Medicine, Faculty of Medicine Centre for Economic Demography, Lund University School of Economics and Management Department of Landscape Architecture, Planning and Management, Swedish University of Agricultural Sciences

More than 100 publications based on registry, survey and biobank data co-authored by SIMSAM Lund participants. In association to the programme 13 PhD students have defended their thesis. Fourteen new PhD students have started their education within SIMSAM Lund Post-docs have been recruited Several courses, seminars and workshops National and international collaborations SIMSAM Lund

SIMSAM Lund – example of articles Associations between gestational complications; gestational diabetes and preeclampsia and air pollution. Malmqvist E, Jakobsson K, Tinnerberg H, Rignell-Hydbom A, Rylander L. Environ Health Perspect. 2013;121: Background A number of studies have shown associations between maternal air pollution exposure and adverse birth outcomes. However; limited information exist for exposure to air pollution and pregnancy complications 81,110 women (singleton births) were linked to individually assessed nitrogen oxides and traffic intensity cases of gestational diabetes, cases of preeclampsia

Emission and meteorological National Road database data

Results NO x (µg/m 3 )OR Gestational diabetes OR Preeclampsia Quartile 1 (2.5-9) 1.00 Quartile 2 (9-14) 1.19 ( )1.28 ( ) Quartile 3 (14-23) 1.52 ( )1.33 ( ) Quartile 4 (over 23) 1.69 ( )1.51 ( )

Maternal smoking during pregnancy and daughters’risk of gestational diabetes and obesity Mattsson K, Källén K, Longnecker MP, Rignell-Hydbom A, Rylander L. Diabetologia 2013;56: Background A study from Norway (the MoBa cohort) showed significant associations However: -Relatively high fraction of non-participants -Smoking data collected retrospectively

Study design Inclusion criteria: -Women born 1982 or later who have had at least one child of their own. - Complete data on relevant variables (smoking, BMI, birth weight etc) -Total of women for the final analyses.

Gestational diabetes Crude OR (95% CI) Adj OR (95% CI) Non-smokers (ref) cig/dag1.73 (1.33, 2.26)1.62 (1.24, 2.13) >9 cig/dag1.68 (1.25, 2.27)1.52 (1.12, 2.06) Non-smokers (ref) cig/dag1.40 (1.32, 1.48)1.36 (1.28, 1.44) >9 cig/dag1.65 (1.54, 1.75)1.58 (1.48, 1.68) Obesitas (BMI>30 kg/m 2 )

Cognitive reserve and dementia – Dekhtyar, S., Wang, H-X., Scott, K., Goodman, A., Koupil, I., Herlitz, A. Dementia is a debilitating process characterized by the loss of memory and cognitive function in old age Variations exist in the extent of neuropathology required for dementia diagnoses To explain the disjunction between the extent of brain damage and its clinical manifestation – RESERVE was suggested Brain reserve: anatomical features of brain structure help tolerate more dementia Cognitive reserve: innate intelligence and stimulating life experiences make brain networks more efficient Cognitive reserve is measured by education or occupational complexity Educational and occupational attainment have social and cognitive prerequisites Early cognitive ability could be a better instrument for cognitive reserve A life-course model of cognitive reserve in dementia is yet to be tested

SIMSAM Lund – Courses and seminars New courses on advanced topics –Family-based designs (Paul Lichtenstein, Johan Hallqvist, Brian d’Onofrio) –Developmental psychology in a life course perspective (Elia Psuoni, Ilona Kuopil) –Bias in observational studies – what can go wrong in Epidemiology? (Jonas Björk) –Collaboration with research schools at the FAS-centre MetaLund and CED at Lund University Open seminars on methodological issues regularly –In collaboration with EpiHealth and FoU-centrum Skåne

SIMSAM Lund – Open seminars Registry-based randomized trials Propensity scores Introduction to DAGs Analysis of cross-sectional data Rasch analysis Bayesian methods Qualitative methods Individual vs. population risk Multiple imputation Validation of the Cox model Age-Period-Cohort modeling... Extensive and highly accessed collection of presentations available on-line

EpiHealth Lund Uppsala EpiHealth Lund Uppsala Centre for Economic Demography Lund Centre for Economic Demography Lund MetaLund LU & LTH MetaLund LU & LTH SIMSAM network SIMSAM network Phd student conferences Courses Interdisciplinary projects Network for PhD-students at SIMSAM Lund

SIMSAM Lund – Cohort inventory Joint initiative with EpiHealth and FoU-centrum Skåne Close cooperation with SND

SIMSAM Lund – Cohort inventory (cont.)

SIMSAM Lund – additional infrastructure initiatives warranted Still too hard for researchers outside the “register-based research clusters” to use registry data –Ethics and legislation –Study design –Data access –Data management –Security issues –...

Consulting and data management facilities Consulting and data management facilities Virtual and physical meeting place Virtual and physical meeting place Common tools, routines and technical platforms Common tools, routines and technical platforms Arena for new collaborations Arena for new collaborations Knowledge transfer Courses Seminars Workshops Knowledge transfer Courses Seminars Workshops SIMSAM Lund Centre for interdisciplinary research based on registries and biobanks Centre for interdisciplinary research based on registries and biobanks

Tack Anna !! för det fantastiska arbete du gjort för oss dessa år