Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B9902080 廖佩炫 B9902095 盧翰生.

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Presentation transcript:

Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). * 組員 B 廖佩炫 B 盧翰生

How nitric oxide is produced? L-arginine + 3/2 NADPH + H O 2 citrulline + nitric oxide + 3/2 NADP +

How nitric oxide is produced? Reduction of inorganic nitrate By Nitroglycerin and amyl nitrite Nitric oxide is generated by phagocytes Nitric oxide is released by neurons 1.Unrelated to body 2.related to body

Effects of nitric oxide to the human body; Vasodilation.(Penile Erection) Mechanisms of NO Action NO is formed diffuses into the blood diffuses into the muscle cells activates guanylyl cyclase dephosphorylation of GTP signalling smooth muscle relaxation

Effects of nitric oxide to the human body; Neurotransmission Modifying electrical activity of neurons

Carbon monoxide Carbonous oxide

How is carbon monoxide produced Generated by the enzyme heme oxygenase (HO) (where it is found in the neurons in the brain or PNS ) - first example Vertebrate body produces small amount of CO During heme metabolism

Production of the Carbon Monoxide

Effects of Carbon monoxide Vasodilation Carbon Monoxide produced activation of calcium-activated potassium channels inducing hyperpolarizing outward currents called STOCs smooth muscle hyper-polarization Vasodilation

參考資料 TW&biw=1076&bih=412&tbs=isch%3A1&sa=1&q=MUSCLE+CELL&aq=f&aqi=g1&aql= &oqhttp:// TW&biw=1076&bih=412&tbs=isch%3A1&sa=1&q=MUSCLE+CELL&aq=f&aqi=g1&aql= &oq= supplement/ center/plasma-blood-protein/hemoglobin-heme-products.html