Online Resource 1. Article title: Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction Journal.

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Online Resource 2. Article title: Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction Journal.

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Online Resource 1. Article title: Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction Journal name: Basic Research in Cardiology Author names: Marc W. Merx*, Simone Gorressen*, Annette van de Sandt, Miriam Cortese-Krott, Jan Ohlig, Manuel Stern, Tienush Rassaf, Axel Gödecke, Mark T. Gladwin & Malte Kelm Corresponding author: Marc W. Merx. M.D. Department of Medicine Division of Cardiology, Pneumology and Angiology Moorenstrasse 5, D Düsseldorf Phone: +49 (0) , Fax: +49 (0)

Online Resource 1 (study flow chart ) nitrite/nitrate in blood plasma n=4 BC+/EC+ n= 34 nitrite/nitrate in blood plasma (baseline) n= 10 deformability of erythrocytes (baseline) n= 15 closed chest model n=32 5min reperfusion n=4 24h reperfusion n=22 24h reperfusion + ETU n=6 nitrite/nitrate in blood plasma n=4 infarct size by TTC staining n=6 24h post ischemia echocardiography n=21 deformability of erythrocytes n=15 nitrite/nitrate in blood plasma n=6 immunohistochemistry n=6 infarct size by TTC staining n=9 nitrite/nitrate in heart tissue n=3 n=1 dead after ischemia induction n=2 dead after blood sample n=3 dead after blood sample BC-/EC+ n= 35 nitrite/nitrate in blood plasma (baseline) n= 11 deformability of erythrocytes (baseline) n= 16 closed chest model n=35 5min reperfusion n=4 24h reperfusion n=25 24h reperfusion + ETU n=6 infarct size by TTC staining n=6 24h post ischemia echocardiography n=19 deformability of erythrocytes n=16 nitrite/nitrate in blood plasma n=7 immunohistochemistry n=6 infarct size by TTC staining n=6 nitrite/nitrate in heart tissue n=3 n=6 LV function Assessment after 24h of reperfusion not possible n=4 dead after blood sample

Figure legend. Online Resource 1 - Study flow chart At baseline either nitrite/nitrate in blood plasma or deformability of erythrocytes was measured. Thereafter, in a closed chest model, animals were subjected to myocardial ischemia/reperfusion injury. After 60 minutes of ischemia animals were divided into three different groups: 1) 5 minutes of reperfusion; 2) 24h of reperfusion 3) 24h reperfusion with NOS inhibition via ETU. Further analysis followed as depicted.