Chapter 4 The Emergence of Neural Fate. PNS Neurons in one Abdominal Hemisegment d v’ l v.

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Presentation transcript:

Chapter 4 The Emergence of Neural Fate

PNS Neurons in one Abdominal Hemisegment d v’ l v

Neurogenesis Lateral inhibition (Notch, delta) Proneural gene expression (achaete, scute) Asymmetric cell division (numb, Notch) SOP pIIa pIIb socket hairsheath neuron Proneural cluster SOP (sensory organ precursor)

achaete scute atonal amos Proneural genes Sensory organs + associated MD neurons solo-MD neurons

93% 91% 50% 26~30% 63% 60% achaete scute atonal amos Proneural genes encode basic-helix-loop-helix proteins bHLH

Determination of SOP cells

Regulation of proneural genes

atonal amos coeloconica trichodea basiconica The development of olfactory sensilla From Goulding et al (2000)

Neurogenesis Lateral inhibition (Notch, delta) Proneural gene expression (achaete, scute) Asymmetric cell division (numb, Notch) SOP pIIa pIIb socket hairsheath neuron Proneural cluster SOP (sensory organ precursor)

Neurogenic mutants Wild type mutants

E(spl) Su(H) Delta Notch E(spl) achaete, scute Notch signalinig

Notch signaling pathway leads to downregulation of proneural genes

sheath hair socket neuron glia ES organ IIBIIA hso shn g SOP Asymmetric Cell Division

Numb SOP Asymmetric localization Notch Numb IIAIIB Cell fate determination

Insc organizer Spindle orientation Pon Numb Miranda Prospero Staufan Prospero mRNA Dlg Lgl Apical Basal