Tyrosine kinase signalling (review) TGF signalling Notch signalling.

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Tyrosine kinase signalling (review) TGF signalling Notch signalling

TGF signalling Receptor Serine/threonine kinase Activation/repression of gene expression SMAD transcription factors and regulators RanGTP, importins and exportins

Flores, A. N. et al. (2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer Nat. Rev. Urol. doi: /nrurol

Flores, A. N. et al. (2014) NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer Nat. Rev. Urol. doi: /nrurol

Numb expression in human mammary tumors. Pece S et al. JCB 2004;167: © 2004 Rockefeller University Press

Loss of Numb expression in tumors is due to enhanced ubiquitination and proteasomal degradation. Pece S et al. JCB 2004;167: © 2004 Rockefeller University Press

Re-expression of Numb selectively suppresses growth in Numb-negative tumors. Pece S et al. JCB 2004;167: © 2004 Rockefeller University Press

Increased Notch signaling in Numb-negative tumors. Pece S et al. JCB 2004;167: © 2004 Rockefeller University Press

Effects of perturbation of Numb or Notch activity in mammary tumor primary cells. Pece S et al. JCB 2004;167: © 2004 Rockefeller University Press