University of Cincinnati Center for Environmental Genetics Biomonitoring and Imaging Facilities and Services Core.

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Presentation transcript:

University of Cincinnati Center for Environmental Genetics Biomonitoring and Imaging Facilities and Services Core

Core Members Glenn Talaska, Ph.D., CIH, Core Leader Marian Miller, Ph.D., Imaging Head Stacey Andringa, RA2, Imaging and Analysis Consultative Resources: Robert Bornschein, Ph.D. Scott Clark, Ph.D., CIH Carol Rice, Ph.D., CIH Howard Shertzer, Ph.D. David Warshawsky, Ph.D. CEG Biomonitoring and Imaging Facilities and Services Core

Services Consultation, Analysis and Training Related to: DNA Adduct Analysis (Talaska, Warshawsky) Carcinogen Metabolites (Warshawsky, Talaska) Radical/Electrophile Scavenger and Enzyme Assays (Shertzer) Mass Spectroscopy Referral (Warshawsky) Imaging and Histological Phenotyping (Miller) CEG Biomonitoring and Imaging Facilities and Services Core

Services (Cont.) Consultation Regarding: Review and Critique Exposure Assessment Strategies (Rice, Bornschein, Clark, Talaska) Selection of Exposure Metrics (Rice, Clark, Talaska) Exposure Reconstruction (Rice) Review Exposure Data (Rice, Talaska) Biological Monitoring (Talaska) CEG Biomonitoring and Imaging Facilities and Services Core

Biomarkers in human and animal studies can: 1.Reduce Misclassification 2. Document the extent of effect modification 1.Exposure : Exposure Interactions 2.Gene : Exposure Interactions 3. Determine Mechanisms 4. Serve as outcome variables

Interactions: Effects of Age, Sex, etc Effects of Chronic Exposure (Cumulative Effects) Effects of Concomitant Exposure Additive Antagonistic Potentiative Synergistic

Arsenic and PAH Interactions Finding the Mechanism(s) of Actions Craig Evans Andy Maier Alvaro Puga Brenda Schumann Glenn Talaska

Arsenic and PAH Disease Interactions Lung Cancer –Smoking and Occupational As exposure –As comutagenesis with DNA-reactive agents? Skin Cancer –Synergy Unknown

R= 0.54 M= 5220 B=-800 P=0.11

Carcinogen-DNA Adducts are Increased in Exfoliated Urothelial Cells of Wives of Smokers: Biological Monitoring of Passive Smoke Exposure Scott Henn, Brenda Schumann and Glenn Talaska Department of Environmental Health

Biomarkers in human and animal studies can: 1.Reduce Misclassification 2. Document the extent of effect modification 1.Exposure : Exposure Interactions 2.Gene : Exposure Interactions 3. Determine Mechanisms 4. Serve as outcome variables