Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine Yun Wang Research Center for TCM Information Engineering Beijing.

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Presentation transcript:

Targeting Systems: New Strategy for Computational Biology in Traditional Chinese Medicine Yun Wang Research Center for TCM Information Engineering Beijing University of Chinese Medicine

Outline Background Systems: the way for TCM to realize the clinical effects Targeting systems A Proposed Platform for System-targeting TCM research A Simple Example

Background Purpose 1: Explain the functional mechanism of TCM Purpose 2: Provide lead compounds for structure optimization Focus on: discovery of active components from TCM Unfortunately: 1. weak effect of the components 2. activity dispersion during component separation 3. no better than “western medicine”, no better than TCM 4. seldom successful stories.

Systems: the way for TCM to realize the clinical effects Fact1: Weak effect of components Fact2: Validated effect of TCM by clinical practice Inference: Interaction among components Direct Interaction (seldom) Indirect Interaction (often) TCM related Biological system Systems are the targets of TCM function TCM function

Targeting systems: interpreting the mechanism of TCM function Direct Interaction (seldom) Indirect Interaction (often) TCM related Biological system Mechanism of TCM function

Targeting systems: bridging biology and TCM theory Direct Interaction (seldom) Indirect Interaction (often) TCM related Biological system TCM function TCM theory

Targeting systems: providing new cues for the treatment of complex disease Direct Interaction (seldom) Indirect Interaction (often) TCM related Biological system TCM function TCM theoryValidated clinical prescription

Targeting systems: providing new resource for drug development Direct Interaction (seldom) Indirect Interaction (often) TCM related Biological system TCM function TCM theoryValidated clinical prescription Impact based molecular target selection “Remote” interruption of systems Complex drugs

A Proposed Platform for System-targeting TCM research Database TCMpathway mol targets Active compnts bio systems

Biological Systems related with TCM Prescriptions that Promoting Blood Circulation and Removing Blood Stasis Map00590:prostaglandin and leukotriene metabolism Map00230: purine metablism Map00100: biosynthesis of steroids Map00531: glycosaminoglycan degradation Map00010: glycolysis /gluconeogenesis

Gaëlle Hardy, et. al. Urinary leukotriene E4 excretion is increased in type 1 diabetic patients A quantification by liquid chromatography–tandem mass spectrometry. Prostaglandins Other Lipid Mediat (1-4): paper’s title in CNKI contaning: promoting blood circulation and removing blood stasis + diabetes

Thanks for Your Attention!