Center for Neural Science Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology Wendy A. Suzuki Center for Neural Science New York University MDRS Chapel Hill, NC 9/25/09

Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

Ventral View of Macaque Monkey Brain TE PH PR ER rs

Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal 30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994

Cortical Inputs to the Perirhinal Cortex TE/TEO 63% STSd 6% TF/TH 25% Insula 2% Frontal lobe 2% Cingulate/Retrosplenial <1% V4 2% Perirhinal Cortex

Cortical Inputs to Area TE Dorsal area TE V4/TEO Frontal area 8 and 45 TF Orbital areas 11 and 13 Perirhinal Parietal (LIPd) Area TE

Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal 30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994

What about the cytoarchitectonic features of these areas?

Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal 30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994

Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

Pair Coding response Individual cell responses in area 36 Naya et al., 2003

Behavioral Learning Curve and Delay Activity Over Time to Scene 653 1 Response (Spikes/Sec) -10 10 20 30 40 50 Baseline Activity 0.8 0.6 Probability Correct 0.4 0.2 10 20 30 40 50 C110600.4 Trials Wirth et al., 2003

Object-Place Association Task Fixation 500ms Cue Delay 700ms Early Late Reward ITI 2000ms + Bar Release Period Early Late + Object 1 Object 2 Place 1 Place 2 Wirth et al, 2009

Conclusions: Pair coding neurons are built in the perirhinal cortex from the sensory input from area TE.

Talk Outline Neuroanatomy of the PRC and area TE Physiology of the PRC and area TE Future experiments

Experiments?