Frontotemporal Dementia

Slides:



Advertisements
Similar presentations
The Memory Assessment and Treatment Service (MATS)
Advertisements

Management of Early Dementia Dr Eleanor Mullan Consultant Psychiatrist Mental Health Services for Older People South Lee, Cork Feb 2011.
“Getting to Know Me” “Getting to Know Me” Enhancing skills in the care of people with dementia in general hospitals. © Greater Manchester West Mental Health.
Martha Stearn, MD Institute for Cognitive Health St John’s Medical Center Jackson, Wyoming.
Parkinson’s Cognitive Problems versus Other Neurological Diseases 14 February 2015 Carole A. Mazurowski, PhD Health Psychology & Neuropsychology 6565 Americas.
Alzheimer’s Disease By Juan Escobar Per: 4. Alzheimer’s Disease  A common form of dementia of unknown cause, usually beginning in late middle age, characterized.
Dementia & Delirium in Surgical Patients Damian Harding Department of Geriatric Medicine February 2008.
Dementia with Lewy Bodies
Mild Cognitive Impairment
How Alzheimer’s Disease Differs from Frontal Temporal Lobe Dementia (Pick’s Disease) Josepha A. Cheong, MD University of Florida Departments of Psychiatry.
A 67-year-old male with behavioral and language problems
NHPA’s Chapter 3. National Health Priority Areas A collaborative initiative endorsed by the Commonwealth and all state and territory governments, which.
Alzheimer’s Disease and Biomarkers John H. Dougherty,Jr.M.D. Medical Director Cole Neuroscience Center.
Alzheimer’s Assessment Assessing the Cognitive-Linguistic effects of Alzheimer’s.
FTD Family Members Study & Post Mortem Study Alyson Negreira MGH Frontotemporal Disorders Unit.
Chapter 15 - Cognitive Disorders I.Delirium Acute, temporary impairment in perception & cognition Fluctuating course.
Non-medication Management of Agitated Behavior in Dementia Patients Josepha A. Cheong, MD University of Florida Departments of Psychiatry and Neurology.
Dementia in Clinical Practice Mary Ann Forciea MD Clinical Prof of Medicine Division of Geriatric Medicine UPHS Photo: Nat Geographic.
Non-Alzheimer’s Dementias
Defining Mild Cognitive Impairment Steven T.DeKosky, M.D. Director, Alzheimer’s Disease Research Center University of Pittsburgh Pittsburgh, PA.
Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 33 Delirium and Dementia.
Jack Twersky, MD Medical Director CLC Durham.  Memory impairment and at least one of the following  Aphasia  Apraxia  Agnosia  Executive function.
 Alzheimer's disease (AD), also known as Senile Dementia of the Alzheimer Type (SDAT) or simply Alzheimer’s is the most common form of dementia. This.
Dr Hussein Farghaly PSMMC
Neuropsychology and differential diagnosis Julie Snowden Cerebral Function Unit Greater Manchester Neuroscience Centre Neuropsychology of Dementia Harrogate,
HOW TO EXAMINE PATIENTS WITH DEMENTIA Serge Gauthier, MD, FRCPC McGill Centre for Studies in Aging Douglas Mental Health Research Institute.
The Dementias Dr Giles Richards Consultant Psychiatrist CFT.
억제적 반응통제 기능의 신경해부학 연구 : 활성화 및 신경화학적 두뇌 기능 영상 PET 연구 Functional Neuroanatomical Study of Inhibitory Response- Control: Activation and Neurochemical PET.
Jalal Jalal Shokouhi – MD
Assessment and Diagnosis of Dementia Dr Alison Haddow.
Focal Syndromes Dr Stephen Pearson Consultant in Old Age Psychiatry Devon Partnership Trust.
Alabama Brief Cognitive Screener (ABCs)
Amyotrophic lateral sclerosis
Cognitive Disorders Chapter 13 Nature of Cognitive Disorders: An Overview Perspectives on Cognitive Disorders Cognitive processes such as learning, memory,
The Alzheimer’s Disease Challenge: Take Your Knowledge Further ALZHEIMER’S DISEASE AND ITS MANAGEMENT: AN OVERVIEW.
Neurobiology of Dementia Majid Barekatain, M.D., Associate Professor of Psychiatry Neuropsychiatrist Isfahan University of Medical Sciences Ordibehesht.
Alzheimer’s disease.
Structural and Functional Neuroimaging in the Diagnosis of Dementia John M. Ringman, M.D. Assistant Professor UCLA Department of Neurology.
By: Azadeh Myers Period 2. Definition A common form of dementia of unknown cause usually beginning in the late middle age, characterize by progressive.
Types of Dementia Dr Bernie Coope Associate Medical Director/Honorary Senior Lecturer, Worcester University Association for Dementia Studies.
Frontotemporal Lobar Degeneration:
This is an umbrella term, not a disease in its own right. It is a term used for a large group of symptoms that adversely affect the brain and can be caused.
DEGENERATIVE DISEASES is a disease in which the function or structure of the affected tissues or organs will progressively deteriorate over time, whether.
Dementia F.Etessam. MD. Dementia A progressive impairment of cognitive functions occurring in clear consciousness.
DEMENTIA 1/6/16 DR TONY O’BRIEN MD FRCP. Dementia Common – 700,000 sufferers in the UK Common – 700,000 sufferers in the UK Prevalence increases with.
The Malfunctioning Mind: Degenerative Diseases of the Brain
59 year old man w visual hallucinations
Dementia with Lewy Bodies
M. M. Dumitru¹∙², V.Chirita¹∙², R.Chirita¹∙²
Dementia Jaqueline Raetz, M.D..
Dementia By Chelsea Carr.
FRONTOTEMPORAL DEMENTIA IN A CASE OF SUICIDAL HANGING
DEMENTIA Shenae Whitfield & Kate Maddock.
By: Johanna Miner, Kendra Hobbs and Ainsley MAcDonald
Dementia: from molecules to minds
Dementia Jaqueline Raetz, M.D..
Seizures in Alzheimer’s disease
Presenter : Dr Aneelraj Co investigators : Dr Srikala Bharath
Imaging AD Progression Amyloid Imaging Agents.
Frontotemporal Dementia
Nat. Rev. Neurol. doi: /nrneurol
Chapter 30 Delirium and Dementia
Reisa Sperling, Elizabeth Mormino, Keith Johnson  Neuron 
Figure 2 Flow chart of patients who met the inclusion/exclusion criteria for the study Flow chart of patients who met the inclusion/exclusion criteria.
Probing the Biology of Alzheimer's Disease in Mice
Chapter 93 Dementias and Related Disorders
The Memory Assessment and Treatment Service (MATS)
Figure 2 A case of early-onset PSD
Axial CT image (A) in a patient with behavioral variant frontotemporal dementia shows a marked frontal atrophy, and axial perfusion SPECT images (B) show.
Presentation transcript:

Frontotemporal Dementia American Academy of Neurology John Hart, Jr., M.D.

Frontotemporal Dementia Definition: clinicopathologic condition consisting of deterioration of personality and cognition assoc. with prominent frontal and temporal lobe atrophy Accounts for up to 3-20% of dementias Third behind AD and Lewy Body Dementia in neurodegenerative dementing illnesses

Prevalence Mean age of onset 52.8 (Ratnavalli et al. Neurology 2002;58:1615-1621) Male preponderance 14:3 in one study and M=F in others Dementia prevalence of 81 per 100,000 (95% CI, 62.8 to 104.5) in the 45-64 year age group Prevalence of AD and FTD in 45-64 age group same at 15 per 100,000 (8.4-27.0)

Frontotemporal Dementia Thus, common cause of dementia in younger population Greater caregiver burden and increased dependency and health care costs

Frontotemporal Dementia Established clinical consensus criteria (The Lund and Manchester Groups, J Neurol Neurosurg Psychiatry 1994;57:416-418; Neary et. al, Neurology 1998;51:1546-1554): Core features Insidious onset and slow progression Early decline of Social interpersonal conduct Regulation of personal conduct Insight Early emotional blunting

Frontotemporal Dementia Supportive features: Decline in personal hygiene and grooming Mental rigidity and inflexibility Distractibility and impersistence Hyperorality Perseverative behavior Speech and language

Frontotemporal Dementia Neuropsychology: Impaired frontal lobe tests in absence of severe amnesia, aphasia, or visuospatial deficits Imaging: Atrophy or decreased uptake in the frontal or anterior temporal lobes (bilateral or unilateral) by MRI, CT, PET, SPECT (The Lund and Manchester Groups, J Neurol Neurosurg Psychiatry 1994;57:416-418; Neary et. al, Neurology 1998;51:1546-1554)

Frontotemporal Dementia

Frontotemporal Dementia

Frontotemporal Dementia Recent study showed of 42 FTD cases, 19 had at least 1 other family member affected (Chow et al., Arch Neurol. 1999;56:817-822) 1/3 had a positive family history in this study, but others much lower Appears to be inherited in autosomal dominant fashion in those patients Linked to chromosome 17 (tau gene) and chromosome 3 Association with motor neuron disease (ALS)

Pathology Prominent frontal and temporal lobar atrophy Atrophy may be associated with Pick’s bodies, tauopathy, nonspecific superficial cortical neuron loss (DLDH)

Frontotemporal Dementia

Frontotemporal Dementia Term is conventionally used in clinical and pathological diagnoses in standard clinical setting No other specific code comes reasonably close to capturing disease Dementia or AD diagnosis (290 or 331) ignores established diagnostic criteria and allows no tracking of FTD

Frontotemporal Dementia Differs from the other codes including AD, frontal dementia, Pick’s disease Use of these codes inappropriate as not capture the age of onset, duration of illness, genetic factors, and impact on caregiver, society, and economics AD  older, different duration, less clear genetics Frontal dementia  no temporal lobe involvement, genetics differ Pick’s disease  not capture spectrum of FTD

Frontotemporal Dementia Implications for FTD different from other dementias/AD: Greater caregiver burden and increased dependency and health care costs Patients see codes and think they have some other disease

Frontotemporal Dementia

Frontotemporal Dementia