Common Regions of the Human Frontal Lobe Recruited by Diverse Cognitive Demands John Duncan and Adrian M. Owen

Frontal Lobe Connectivity –Modules? Frontal functions Network of prefrontal regions involved in diverse cognitive tasks

Cognitive Demands Response conflict Novelty Working memory: number of elements Working memory: delay Perceptual difficulty

Isolation of a Cental Bottleneck of Information Processing with Time-Resolved fMRI Paul E. Dux, Jason Ivanoff, Christopher L. Asplund, and René Marois

Central Bottleneck Central, amodal processing stage Psychological refractory period Time-resolved fMRI

pLPFC Coactivation by contrasting tasks Serial postponement of activity

Implications SMFC as well as pLPFC Correspond to mid-dorsolateral and anterior cingulate –Recall Duncan & Owen (2000) Diverse cognitive functions, but limitations

An Integrative Theory of Prefrontal Cortex Function Earl K. Miller and Jonathan D. Cohen

PFC Top-down control –Access to range of information –Multimodal –Maintain and update representations –Exert biasing signals to other regions –Plasticity