ERYTHROPOEISIS RBC Basophilic Polychroma- Orthochroma- Hemocytoblast

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Presentation transcript:

ERYTHROPOEISIS RBC Basophilic Polychroma- Orthochroma- Hemocytoblast Proerythroblast Erythroblast tophilic tophilic Nuclear Reticulocyte Erythroblast Erythroblast Extrusion 1. dispersed 1. clumped 1. condensed 1. condensed 1. anucleate Pluripotential chromatin eccentric chromatin chromatin Stem Cell nucleus 2. spherical 2. grey-green 2. nucleoli 2. no 2. pink cytoplasm 3. slight nucleoli cytoplasm basophilia (hemoglobin 3. cytoplasmic 3. maximum (free ribosomes) synthesis) basophilia basophilia

Erythropoeisis- Several Stages

MYELOPOEISIS Hemocytoblast Myeloblast Promyelocyte (granulopoeisis) (multipotential) (multipotential) Promyelocyte (multipotential) 1. loss of cytoplasmic basophilia 2. dispersed chromatin Eosinophilopoeisis Neutrophilopoeisis Basophilopoeisis

EOSINOPHILOPOEISIS Eosinophilic Eosinophilic Eosinophil Myelocyte Metamyelocyte (band cell) Specific and Metachromatic Granules

Eosinophilopoeisis- Several Stages

NEUTROPHILOPOEISIS NEUTROPHILIC NEUTROPHILIC MYELOCYTE METAMYELOCYTE

MYELOPOEISIS (Several Stages) Nutrophilic Band and Neutrophilic and Eosinophilic Band Cells Eosinophilic Metamyelocyte

BASOPHILOPOEISIS Basophilic Basophilic Myelocyte Basophil Metamyelocyte

THROMBOPOEISIS Endomytosis Reserve Megakaryocyte (megakaryoblast) (w/o karyokinesis Hemocytoblast (w/o cytokinesis) Reserve Megakaryocyte (megakaryoblast) Platelet-Forming Megakaryocyte Residual Megakaryocyte Platelet-Shedding Platelets (fusion of plasma membrane)

MEGAKARYOCYTES

BONE MARROW Decalcified Bone and Marrow Marrow Cavity Fat Cells Bone

Marrow Endothelial Cells Megakaryocyte Diapedesis Adipocyte Discontinuity Blood Sinusoid Reticular Hemopoetic Fibers Compartment

Bone Marrow Bone Marrow in Decalcified Bone Bone Marrow Smear