Effects of Microgravity and Space Flight on Macrophages Stephen Keith Chapes Division of Biology, Kansas State University.

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Presentation transcript:

Effects of Microgravity and Space Flight on Macrophages Stephen Keith Chapes Division of Biology, Kansas State University

Macrophages Respond to Microgravity in Seconds

Bone Marrow Macrophage Growth is Enhanced During Space Flight

Bone Marrow Macrophage Differentiation is Inhibited During Space Flight

Space Flight Enhances Macrophage Cytokine Secretion

B6MP102 Macrophage Cells Growing on Cytodex Beads

Cartoon of the Bioprocessing Units Used to Assess Macrophage Cytokine Secretion

Conclusions Macrophages respond to microgravity within 8 seconds. Space flight makes bone marrow cells proliferate faster but it slows the rate at which bone marrow cells differentiate into macrophages. Space flight increases the concentration of cytokines the macrophage cell line, B6MP102, secretes. THESE DATA SUGGEST THAT MACROPHAGES ARE AFFECTED BY MICROGRAVITY AND SPACE FLIGHT.

References Chapes, S.K., E.S. Didier and W.A.F. Tompkins Macrophage cell line B6MP102 resembles peritoneal macrophages in tumor cell recognition and killing. J. Leukoc. Biol. 43:28 ‑ 35. Chapes, S.K., D.R. Morrison, J.A. Guikema, M.L. Lewis and B.S. Spooner Cytokine secretion by immune cells in space. J. Leukoc. Biol. 52: Armstrong, J.W., R.A. Gerren and S.K. Chapes The effect of space and parabolic flight on macrophage haematopoiesis and function. Exp. Cell Res. 216: