BSc Haematology Basic biology of blood Molecular basis of disease Novel treatments/cures Meet the patients in clinics Clinically-applied science Learn generic skills

Teaching takes place on two Campuses: - St Mary’s Hospital - Hammersmith Hospital Generally, teaching is done in blocks On any day is only on one Campus BSc Haematology

Part A Introduction to; 1) Haemoglobinopathies 2) Blood Transfusion, 3) Leukaemia 4) Haemostasis, 5) Scientific methods 6) Generic Skills 3. Red Cells & Erythropoiesis. Thalassaemias & Haemoglobinopathies 1. Haemostasis, Abnormal Haemostasis (Bleeding vs Thrombosis) 2. Leukaemia, Lymphoma, & Multiple Myeloma BSc Haematology 1x 2-week Introductory Course (Part A) Part B 3x 5-week Course Modules (1-3 – Part B) Part C Research Project Clinical or Lab (..or Taught Course)

1.What are the components of a haemostatic plug? 2.How does our body respond to vessel damage Module 1: Haemostasis Fibrin RBC Platelet aggregates Leukocyte

1.What are platelets for? 2.What is primary haemostasis? 3.Why can people with thrombocytopenia or VWD bleed? 4.How do antiplatelet agents (aspirin, abciximab or clopidogrel) work and why are they useful? Module 1: Haemostasis

1.What is secondary haemostasis? 2.How does this complex start clotting? 3.How are these images obtained 4.How are new antithrombotics designed from such images? Module 1: Haemostasis

This boy has Haemophilia A 1.Why does he bleed? 2.Why don’t any of his sisters bleed? 3.How can he be treated to lead a normal life? 4.How has protein engineering improved his prospects? 5.Will gene therapy provide a cure? Module 1: Clinical Haemostasis - bleeding

This woman has DVT 1.How is thrombosis manifest? 2.What are the risk factors for thrombosis? 3.How safe are long haul flights and the pill? 4.How do anticoagulants and antithrombotics work? Module 1: Clinical Haemostasis - thrombosis

1.What causes leukaemia? 2.How does understanding the science help us manage patients? 3.Do new wonder drugs (like imatinib) cure leukaemia? Module 2: Leukaemia, lymphoma, multiple myeloma

This little boy has leukaemia 1.Why does leukaemia occur? 2.How do such diseases present and how are they diagnosed? 3.How can a disease be acquired and yet be due to defective genes? Module 2: Leukaemia, lymphoma, multiple myeloma

This elderly lady has enlarged lymph nodes? 1. Could this be leukaemia? 2. How would you find out? 3. Can gene profiling improve diagnosis? Module 2: Leukaemia, lymphoma, multiple myeloma

This middle aged lady died from a blood transfusion? 1.Why are transfusions required and what are the risks? 2.What are blood groups? 3.What is the progress on alternatives to blood transfusions? Module 3: Red cells, thalassaemias & haemoglobinopathies

This little boy has β-thalassaemia major 1. How is this condition inherited? 2. How can one relate his genetic abnormality to the clinicopathological features? 3. How can our understanding of disease inform treatment? Module 3: Red cells, thalassaemias & haemoglobinopathies

1.How does the haemoglobin molecule function? 2. How can haemoglobin make the red cell change its shape? 3.Why is this harmful? 4.What are the risks associated with SCD and what can we do about it? Module 3: Red cells, thalassaemias & haemoglobinopathies

These patients’ bone marrows have failed. 1.Why might fingers be altered by bone marrow failure? 2.How can inherited and acquired abnormalities lead to bone marrow failure ? 3.What are the therapeutic options and how might these be improved? Module 3: Red cells, thalassaemias & haemoglobinopathies

~30 lab/clinical projects available. Haematology projects (and the alternative taught modules) are allocated on the basis of student choice and then academic achievement. Module 4: Research project “ADAMTS13 and its role in Von Willebrand Disease" “Cloning of leukaemia cell lines transduced with fusion oncogenes” "The expression of human telomerase RNA and dyskerin mRNA in patients with dyskeratosis congenita" “Sensitivity of leukaemia cell lines to new cytotoxic drugs” "The Role of the Fetal Mesenchymal Stem Cell in Megakaryopoiesis" “Regulation of stem cell proliferation by interaction with lymphocytes” “Centrosomal proteins in chronic lymphocytic leukaemia?” “Does HIV infection complicate the diagnosis of thalassaemia?” Projects mainly on Hammersmith Hospital Campus; a smaller number are at St Mary’s

Publications from past students include: Note: Publication of work from projects requires both originality and quality!!!

Very popular course! Friendly teachers who really want to impart their knowledge and help you discover things for yourselves. Internationally renowned clinicians & scientists Can accept 40 students. Haematology BSc - Overview

“I really enjoyed the BSC and project. The project was the biggest thing I have done.” IW “I thoroughly enjoyed my Haematology BSc and project.” AM “I enjoyed this year, I gained transferable knowledge, improved research & writing skills.” CD “The course was not my first choice….I would now consider haematology as a speciality.” PH “A good mix of clinical and experimental medicine with all modules very well taught.” ZI “I thoroughly recommend this course as it covers a wide range of diseases that are of major clinical significance. It is well taught and supervisors are friendly.” SB Comments for past Haematology students

A BSc that is of great clinical relevance Thrombosis & cancer Thrombosis & cardiovascular disease Bleeding/thrombosis & surgery Sepsis Cancer biology Leukaemia Transfusion SCD Thalassaemias Diagnosis & treatment Genetic & molecular bases of disease An opportunity to understand an exciting branch of medicine in the forefront of many scientific advances A unique opportunity to meet patients with the disease you are studying-from DNA analysis to the bedside Haematology BSc - Overview

BSc Haematology Basic biology of blood Molecular basis of disease Novel treatments/cures Meet the patients in clinics