A Short Introduction To Platelet Rich Plasma Therapy.

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Presentation transcript:

A Short Introduction To Platelet Rich Plasma Therapy

Blood Components -93 % RBCs -6 % Platelets -1 % WBCs -Plasma(Liquid Component) PRP - 94 % Platelets and Plasma - 5 % WBCs

Function of Blood Cells Leukocytes ; Infection Removal Bacteria Erythrocytes; Oxygen Transport Platelets; Blood clotting and wound healing.

Platelets Platelets derived from megokaryocytes Important in Hemostasis/Clotting Platelets are normally activated during the inflammatory phase to begin healing Role in the normal healing response via the secrection of local growth factors Growth factors released by platelets recruit reparative cells and augment soft-tissue repair

What Is PRP Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.

PRP Application Areas Orthopedic and Traumatology Maxillo-Facial Surgery Plastic/Reconstructive Surgery Cardiac Surgery Cosmetic Surgery General Surgery Sports Medicine Hair Transplantation Skin Rejuvanation

Platelet Growth Factors Growth Factor Transforing Growth Factor –Beta TGF-β Basic Fibroblast Growth Factor, bFGF Epidermal Growth Factor EGF Vascular Endothelial Growth Factor VEGF Connective Tissue Growth Factor CTGF Sources Platelets,extra cellular matrix of bone, Cartilage matrix,activated TH cells and natural killer cells,macrophages/monocytes And neutrophils. Platelets,macrophages,mesenchymal cells,chondrocytes,osteoblasts Platelets,macrophages,monocytes Platelets,endothelial cells Platelets through endocytosis from extra- Cellular environment in bone marrow.

Action of PRP Growth Factors

Healing Cascade

Platelet Count Normal Platelet CountConcentrated Platelet Count

Cellular Factors İn Wound Healing

Benefits of PRP in the Healing Cascade

Easy PRP Kit

Advantages Easy to use High concentrated PRP Buffy Coat Cost Effective Simple Operation No Contamination by Pathogens Convenient for Office use

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