Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Whole Slide Image System Implementation Jeffrey Fine MD University of Pittsburgh.

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Presentation transcript:

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Whole Slide Image System Implementation Jeffrey Fine MD University of Pittsburgh

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Objectives Present rough framework for implementing whole slide image (WSI) technology Discuss examples of WSI implementation Discuss potential justifications or funding sources

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Framework for Implementation What will virtual slides be used for? Who will use them? Is there a sound business case –If not, how will one justify the cost and effort?

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Possible Applications Education Clinical Meetings Quality Assurance –Precious slides (cytopathology, frozen sections) –Proficiency testing Other Clinical Applications –Electronic distribution of stains –Consultation

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Classes of Users “Mission Critical” –Pathologists for patient care activities –Technical and/or administrative support for above Others (potential tier in no particular order) –Clinician colleagues –Researchers –Residents (educational not service) –Students

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 User Expectations Continuous availability no matter what –Technical support, recovery ability, etc. “Quick” performance no matter how many other users are present Security Good Workflow

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Implementation Needs drive system plans –Scan capacity (how many robots; how fast) –Storage capability and Network capacity –Ancillary systems (bar codes; slide quality, real APLIS integration) Fund or justify WSI system cost –(in a few minutes)

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Challenges Current WSI implementations mostly limited to lowest tier –Education and research Cost –Not justified rigorously –Funded via research grants predominantly Not “mission critical” –No optimized workflow/integration –Support/availability not formally defined

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Example: UPMC Education –Several systems and thousands of WSI Research –QA, primary diagnosis, and IHC stain distribution Patient Care –Frozen Section QA Service (new)

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Frozen Section QA Service Purpose –Improve performance (error rate and deferral rate) both by UPMC faculty and by trainees in the future Initial application –Retrospective collection of cases with discrepant frozen sections (previous five years) –Distributions of WSI for formal review and for educational review Expansion –Ongoing review of frozen section slides

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Users Pathologists (reviewers) –Workflow Not yet well-supported by vendors May evolve over time –Availability Not “mission critical”; small user base Residents (educational) –Small volume and can use existing educational “workflow”

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Justification QA is a high priority –Cost effectiveness poorly understood Equipment and personnel already in place –Eases funding transition from research to “operational” Low volume application

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Other Benefits Digital archive of FS slides –Protects original slides from handling –Permits viewing by many simultaneously No transportation costs Slides widely available at all campuses for residents and faculty

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 WSI Example: US Labs WSI of slides by request –(200 images daily) Upcoming expansion to image all IHC slides (800 images daily)

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Users Pathologists for patient care –“Mission critical”

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Justification Decreased turnaround time –WSI would be available hours earlier than conventionally shipped glass slides Decreased shipping cost Customer satisfaction –WSI are popular with several customers –Other customers could be accommodated as before with traditional shipping

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Practical Details (US Labs) Images are stored for 30 days then purged –Customers receive glass slides for permanent record –Otherwise storage requirements would add more cost Slide throughput –Multiple high-speed scanning devices, in parallel Customers perform own validation using glass slides as gold standard

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Future Expansion Utilization of WSI for image analysis service –Currently uses “static” images of glass slides since 1999

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Discussion: Funding/Justification Research funds –Government entities (including the military) –Collaboration with vendors Departmental funds –Rigorous justification –Documentation Were expected savings realized? Was patient care enhanced?

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Slide Archival Rapid review of prior pathology case –No time or courier costs for retrieval –Increased compliance with this basic QC procedure (enhanced patient care) –“Retention” of outside pathology material Archival of “precious” slides –Frozen sections, cytopathology slides, etc. Access for conferencing, education, research, or consultation

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Electronic Slide Distribution US Labs example Decreased turn-around time and shipping costs Could be expanded to other modalities –Routine histology; special stains; FISH; etc. More efficient projection of service by pathology departments at large multi- campus healthcare organizations

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Image Analysis Immunohistochemistry and FISH –WSI not required but could decrease manual labor associated with imaging step of image analysis –Potential revenue Other Computer-Assisted Diagnosis (CAD) activities

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Revenue Direct justification for WSI service Possible revenue from newly billable activities involving image analysis –IHC analysis a potential “foot in the door” for digital pathology and WSI in particular

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Unusual Funding Sources Clinical departments –Sub-specialty environment facilitates closer relationship with individual groups of clinicians –Justifications include conferencing, research, non-pathology resident education, QA, consultation, etc. Funded provision of telepathology services to underserved regions or countries

Wednesday August 16, 2006 APIII 2006 Vancouver Breakout Session A2 Acknowledgements Anil Parwani Drazen Jukic Yukako Yagi Ashok Patel Steve Jones (US Labs)