PowerPoint Slides for Chapter 1: Heritable Material by A. Malcolm Campbell, Laurie J. Heyer, & Christopher Paradise 1.3 Can you prove protein is NOT the heritable material? Integrating Concepts in Biology Title Page Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Biology Learning Objectives Interpret data showing that DNA is the heritable material and protein is not. Evaluate experimental design and analyze data from research on DNA as molecular information. ELSI Learning Objectives Critique the common misconceptions about DNA evidence in trials. Argue whether other people have the right to access your DNA information. Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Fig. 1.4 R strain S strain Transforming Factor from S Cells courtesy of Abagael Slattery and from Belanger et al. 2004

Fig. 1.5A Twenty Amino Acids for Code Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Fig. 1.5B 4 phosphates (long bonds stretched for clarity only) Four Nucleotides for Code Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Bacteriophage Infecting E. coli Fig. 1.6 Image by Graham Beards. 2008

Phage Made of Protein and DNA Fig. 1.6 Image by Graham Beards. 2008

Hershey & Chase Experiment Fig. 1.7A Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Fig. 1.7B Hershey & Chase Experiment infection 5 minutes Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Fig. 1.7B Hershey & Chase Experiment infection 5 minutes Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Hershey & Chase Results Fig. 1.8 DNA protein from Hershey and Chase, 1952.

Hershey & Chase Results Fig min. incubation, then blender DNA protein from Hershey and Chase, 1952.

Hershey & Chase Results Fig. 1.8 DNA protein How long should they blend? from Hershey and Chase, 1952.

Hershey & Chase Results Fig. 1.8 What is transmitted to progeny? DNA protein from Hershey and Chase, 1952.

Hershey & Chase Results Fig % proteins outside bacteria from Hershey and Chase, 1952.

Hershey & Chase Results Fig % DNA inside bacteria from Hershey and Chase, 1952.

Hershey & Chase Results Fig. 1.8 proteins probably NOT heritable material from Hershey and Chase, 1952.

Hershey & Chase Improved Data Table 1.2 Table 1.2. Location of phage protein and DNA after infection of E. coli. from Hershey and Chase, 1952.

Table 1.2 Table 1.2. Location of phage protein and DNA after infection of E. coli. Hershey & Chase Improved Data from Hershey and Chase, 1952.

Table 1.2 Table 1.2. Location of phage protein and DNA after infection of E. coli. Hershey & Chase Improved Data 1% of protein inside 70% DNA inside from Hershey and Chase, P- DNA refined experiment 35 S- protein refined experiment

Table 1.2 Table 1.2. Location of phage protein and DNA after infection of E. coli. Protein NOT Heritable Material some virus progeny contained 32 P DNA from Hershey and Chase, P- DNA refined experiment 35 S- protein refined experiment

4 Myths of DNA Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

4 Myths of DNA 1. DNA sequencing is super fast 2. whole genome sequenced 3. DNA convicts the guilty 4. DNA evidence is perfect Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.

Innocence Project ELSI Web Resource

Innocence Project ELSI Web Resource

1906 Understanding of Genetics ELSI Fig. 1.2 from American Philosophical Society, 1906.

1906 Understanding of Genetics ELSI Fig. 1.2 from American Philosophical Society, 1906.