Susan Pacconi Senior Manager, Global Scientific Communications, Celgene Corporation March 27, 2015 Making it Fit: Building Integration, Collaboration, and Trust among HEOR and Scientific Publications Teams

Disclosures Please note that the views and opinions expressed in this presentation are my own, and do not necessarily reflect those of Celgene Corporation.

So, by now it’s loud and clear, HEOR and Scientific Publications Plans are similar, but clearly different The Steps in Publication Planning may be similar, but there are clear differences in HEOR and scientific publications:  Audience  Analysis  Clinical Trial vs Retrospective vs Prospective  Writing Style  Target journals  Timing

HEOR and Publications Reporting Structures Reporting structures are variable for HEOR teams Does this impact your teams ability to plan and communicate cohesively? ISMPP survey and roundtable discussion 2013

The Obvious Differences  HEOR isn’t Clinical and Clinical isn’t HEOR  Be open to what works versus trying to retrofit New England Journal isn’t looking for the same information as Pharmacoeconomics Provide the right content, to the right audience, in the right journal

The Right Content Medical/ClinicalHEOR EfficacyHealth Utility SafetyPharmacoeconomics Overall SurvivalCost Effectiveness Adverse EventsDirect/Indirect Costs Weigh out the content appropriately for your reader.

The Right Audience Medical/ClinicalHEOR PhysiciansPayer NursesP&T Committees PharmacistsEmployer PatientsPatient StudentsGovernment Patient Advocacy Some audiences overlap. It’s important to consider your primary audience when writing the publication.

The Right Journal Knowing the Right Target Saves Time and Resources Of note: with HEOR’s growing importance, many of the top scientific journals are starting to publish HEOR. Medical/ClinicalHEOR NEJM American Journal of Managed Care Leukemia Value in Health JAMA Journal of Health Economics and Outcomes Research Annals of Internal Medicine Journal of Managed Care & Specialty Pharmacy (JMCP) British Medical Journal American Journal of Health- System Pharmacy (AJHP) Nature Journal of Clinical Epidemiology

HEOR & Traditional Publications Should be Planned Together Sources of Data are Vast and Far Reaching Publications Pharmacists Nurses Payers HCPs Scientists Patients Students Caregivers Gold Standard: RCTs Real World Evidence HEOR research provides Real-World Data to external stakeholders casting a wider net beyond traditional publications— covering current scientific, health economic, and health policy research

How do we INTEGRATE the two?  Identify your key players in the HEOR and Publications teams Communicate effectively and efficiently  Ensure alignment on the development and delivery of publications Participate in meetings together and share updates/key learnings  Make the integration part of the teams goals and objectives If you know their plan, and they know yours, it becomes ONE Plan

Interplay Between the Teams—Communication Should be Multi-Directional As a Medical Writer, Publications Professional, Journal Editor, Statistician, HEOR/CRO, how do you open the lines of communication?

The Steps to COLLABORATION 5 Steps to Successful Collaboration 1.Identify the right type of collaboration for your particular team 2.Secure leadership support in your goals 3.Use great process, but be flexible! 4.Allow time 5.Reset the dial when necessary

Lead the way and IMPLEMENT Change So, let’s get to the tough question. Why aren’t we comfortable sharing strategy?  Transparency  Trust  Territory

When Vision Becomes Reality The importance of alignment among colleagues isn’t much different than Ford’s vision of the value of an assembly line Produce Results Teamwork/Implementation Identify a Gap or Need Do you see the parallels? “Ford had a global vision, with consumerism as the key to peace. His intense commitment to systematically lowering costs resulted in many technical and business innovations”

| 15 Planning Makes the Seemingly Impossible, POSSIBLE  Include HEOR in all publication planning & vice versa  Communicate frequently and participate in strategic discussions  Agree upon appropriate target congresses/journals  Manage the timeline by proactively managing the team  Statistics  Medical  Clinical  Vendors  Authors Planning makes the impossible POSSIBLE!