Ahmed El-Sohemy Canada Research Chair in Nutrigenomics Department of Nutritional Sciences University of Toronto Caffeine, Genetic Variation and Risk of.

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Presentation transcript:

Ahmed El-Sohemy Canada Research Chair in Nutrigenomics Department of Nutritional Sciences University of Toronto Caffeine, Genetic Variation and Risk of CVD

 Founder and shareholder – Nutrigenomix Inc. Disclosure

“The Legal Alternative” 280 mg Caffeine

Caffeine (1,3,7-trimethylxanthine)

Caffeine from Energy Drinks ≠ Caffeine from Coffee Hot beverage that is sipped slowly is not like a cold beverage that is often chugged.

Increase Decrease No Effect Genes Genotype A Genotype C Genotype B CVD Coffee Is Coffee associated with CVD?

caffeine magnesium potassium polyphenols aliphatic acids diterpenoids melanoidins Bioactives in coffee

Caffeine CYP1A2 1-methylxanthine 1-methyluric acid 5-acetylamino-6- formylamino-3- methyluracil 1,7-dimethyluric acid Paraxanthine

slow fast Genetic Variation in CYP1A A  C

2013 cases (myocardial infarction) 2013 population-based controls - matched (age, sex, area of residence) Data collection: - food frequency questionnaire - health and lifestyle questionnaire - fasting blood sample (DNA) Costa Rica Heart Study

* * P<0.05 Cornelis et al., JAMA 295: , 2006 Coffee Intake and Risk of Myocardial Infarction

* P<0.05 * * Cornelis et al., JAMA 295: , 2006 Coffee Intake and Risk of Myocardial Infarction

Subjects <50 Years of Age * P<0.05 * * * * Cornelis et al., JAMA 295: , 2006

Palatini et al., J Hypertens 27: , 2009 Coffee Intake and Risk of Hypertension * P<0.05 * * *

Personalized Dietary Advice Public Health Recommendations vs

Research to identify genetic sub-groups at risk Regulations to protect vulnerable sub-groups Future Directions

Marilyn Cornelis Ilana Platt Bénédicte Fontaine-Bisson Leah Cahill Karen Eny Clare Toguri Daiva Nielsen Bibiana Garcia Bailo Stephen Ozsungur Laura Da Costa Christine Asik Erica Day Tasevski Joanne Brathwaite Cristina Cuda Lilli Mauer Andre Dias Hyeon-Joo Lee Dennis Wang Ouxi Tian Nanci Guest Susana Huang Lindsay Stewart Alejandra Navarro-Allende Nora Khataan Darren Brenner Joseph Jamnik Karina Fisher Andrea Josse Hannia Campos Paolo Palatini Guang Sun Tom Wolever David Jenkins Alaa Badawi Lisa Cameron Acknowledgements

Canada Research Chairs Canadian Institutes of Health Research Natural Sciences and Engineering Research Council Advanced Foods and Materials Network Centres of Excellence Nutrigenomix Inc.