Welcome to Quertle Find What Matters ™ © 2011 Quertle, LLC

Introductions Issues and Solutions –The problems Quertle has addressed  –Insights into how to best use Quertle Live searching –Query strategies –Key features Training Session Outline

Vicki Burnett, Ph.D. –Molecular Toxicology –Text Mining –Data Analysis Jeffrey Saffer, Ph.D. –Molecular Biophysics and Biochemistry –Text Mining –Information Visualization Quertle Principals

Sometimes a search gives so many results that it is nearly impossible to find what really matters –Too many irrelevant results –Too hard to explore the sheer numbers Issue: Too Many Results Gulp!

Relationship-based searching Intuitive exploration Solution: Quertle Provides…

Relationships vs. Keywords “While having my morning caffeine, my blood pressure really rose when I read about the person whose oxycodone abuse caused death.” This sentence is not relevant to: “caffeine’s effects on blood pressure” There are multiple keywords, but only one relationship! What’s relevant?

Subject-Verb-Object triplet representing an assertion by the author –“streptozotocin induces diabetes” Relationships are order independent –“diabetes is induced by streptozotocin” A sentence may have multiple relationships –“While streptozotocin causes diabetes, alloxan also induces diabetes” What are Relationships?

Search for “Diabetes and Cancer” Want to find “Diabetes is well known to be associated with pancreatic cancer” 1 but not “Curcumin has been used to treat cancer, diabetes and other pathologies” 2 even though each sentence contains both terms Benefit of Relationship Searching 1 Perrin et al, 2007, BMC Med 2 Tikoo et al, 2008, Br J Pharmacol 153: 1225

Use all or parts of a relationship caffeine affects sleep caffeine affects affects sleep Verbs are not required, but can significantly focus a search Use additional qualifiers, including dates, as filters on the Results page Searching for Relationships caffeine sleep caffeine sleep

A general search “diabetes induces” will get diabetes as subject OR object (diabetes induces __) or (__ induces diabetes) Use “what” to clarify your intention “diabetes induces what” will return only diabetes as subject “what induces diabetes” will return only diabetes as object Search Tip – Be Clear

Case-sensitive searching supported –NO; MAID Separate entry box for author names –Benedict syndrome Searching informative text –Not References, Acknowledgements, etc. Extensive ontology –All synonyms will be automatically applied –Enables searching for categories To Support Effective Searching

Desired Query: arsenic affects what diseases? What you want: arsenic affects cancer arsenic affects diabetes arsenic affects Alzheimer’s arsenic affects stroke arsenic affects COPD arsenic affects neurodegeneration arsenic affects anoxia arsenic affects inflammation … Searching for Categories I’ll be at this all week!

Power Terms represent classes of entities, e.g., $Diseases Allows you to query for all members of the class in a single bound Regular ($) vs. “automatic” Power Terms Let us know what other Power Terms you want Introducing Power Terms™ query

To Support Effective Exploration Clear indication of relevance –Results sorted by relevance Optional date sorting –Highlighting in context –See relevant relationship(s) –View abstracts right on the results page Intuitive navigation of the results –Automatic Key Concept extraction –Dynamic filtering Easy connectivity

Quertle Demonstration

–Find definitions in the context of actual documents Search Tip – Find Definitions

D –Get some results –“interact”, per se, may be too limiting if you are looking for any effects (“cause”, etc.) No need for (Vitamin B12 or cobalamin or …) and (metformin or 1,1-dimethylbiguanide or …) –From Key Concepts, immediately see The main action is to “decrease” “Malabsorption” is a contributor Structuring Searches

$Diseases means everything bad (e.g., oxidative stress), not just named diseases Power Term members found in relationships are listed in the Key Concepts filter What other Bad Effects?

Focus search on core relationship –Add qualifiers as filters MeSH are searched under Keyword Results, but are not relevant to Relationships Quertle find the concepts in any order, so phrase searching is not needed (nor supported) All aliases and synonyms are automatically applied, so no Boolean is needed Excluding terms (NOT) is not currently supported Enter Authors in separate field –Finds all of the entered names Enter Journals in separate field –Finds any of the entered names Save searches and get automatic alerts (MyQuertle) Check out the Help and FAQ pages Key Points – Searching

An individual will be listed many ways –Saffer J –Saffer JD –Saffer Jeffrey –Saffer Jeffrey D To find all forms of a name, use the lowest common denominator Search Tip – Authors

Sort by Relevance or Date Also Containing filter –Applied to all informative text; can add multiple filters Publication Date filter –Only the listed options are available at this time –To see early documents, sort by date and look at the last pages Key Concepts filter –Derived from and applied only to the relationships –Apply one at a time Publication Type filter –Finds any of the selected types Easy export to bibliographic management tools Easy access to full-text articles –Single click on PDF icon (when shown) –Connect to your holdings through any OpenURL-compliant resolver (see Key Points – Results

More is not better! Only more relevant information is better. Remember: