HES1 Is a Master Regulator of Glucocorticoid Receptor– Dependent Gene Expression by Javier R. Revollo, Robert H. Oakley, Nick Z. Lu, Mahita Kadmiel, Maheer.

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HES1 Is a Master Regulator of Glucocorticoid Receptor– Dependent Gene Expression by Javier R. Revollo, Robert H. Oakley, Nick Z. Lu, Mahita Kadmiel, Maheer Gandhavadi, and John A. Cidlowski Sci. Signal. Volume 6(304):ra103-ra103 December 3, 2013 ©2013 by American Association for the Advancement of Science

GR signaling represses the expression of HES1. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

Glucocorticoids require RelA (p65) to repress HES1. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

HES1 alters GR signaling. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

HES1 requires DNA binding to inhibit GR signaling. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

Glucocorticoids repress HES1 expression in hepatocytes. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

Ablation of liver HES1 alters GR signaling. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

HES1 regulates glucocorticoid-mediated IGFBP1 gene induction. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science

Glucose tolerance tests. Javier R. Revollo et al., Sci. Signal. 2013;6:ra103 ©2013 by American Association for the Advancement of Science