RABIES VIRUS

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Morphology and structure Replication Pathogenesis Clinical symptoms Diagnosis Prevention and Treatment

Morphology bullet-shaped; 45-100 nm in diameter; 100-430 nm long.

structure Capsid N-protein Core -ssRNA Envelope L-protein (large protein) ---RNA dependent RNA polymerase RNP Capsid N-protein ---protect RNA from hydrolysis P-protein Envelope Bilipid layer M-protein (matrix protein) G-protein (glucoprotein) ---spike ---bind to the receptor of the host cell

Rabies is an RNA virus. The genome encodes 5 proteins designated as N, P, M, G, and L. The order and relative size of the genes in the genome are shown in the figure below. The arrangement of these proteins and the RNA genome determine the structure of the rabies virus.

Replication Adsorption Penetration Uncoating Biosynthesis Assembly and release

biosynthesis -ssRNA RNA polymerase +ssRNA -ssRNA protein virus

Pathogenesis CNS afferent fibers efferent fibers nerve endings salivary gland Neuromuscular organs and tissues junction muscles Virus

Clinical symptoms Early stage (1-3days) fever(37.5-38) vomit wound:pain,red,itching Exciting stage(1-3days) fever(39-40) hydrophobia:pharyngeal muscle cramp,dyspnea dehydration Paralytic stage(15-20hs) nerve fiber paralysis respiratory and circulatory failure death

Diagnosis Isolating the dog(7-10days) Pathogenic history cerebral smear or slice immunofluorescent stain

Prevention and treatment Kill wild dogs Keep away from dogs Clean the wound Passive immunity vaccine

Contributers Bian Shu Cong Ping Mu Xueru Shao Cong Zhang Jingjing Zhu Wenying Cheng Wei Hu Chen Li Yuntao Li Daowei Wang Shengxi

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