Ravi Chacko CEO Chase McCaleb CFO Walker Plash CMO Perry Yin CTO George Zhou CRO

ACL Injury 100, ,000 rupturs per year 1 60,000-75,000 ACL reconstructions are performed annually 2 Surgery > $10,000; Rehab >$10,000; Time ~ 1 year 3 Lifelong effects (i.e. Patellofemoral Syndrome, Osteoarthritis) No currently available options for general risk assessment aimed towards prevention 1. Mayo Clinic Online 2. JD Hubbell, MD; E Schwartz, MD; 3. WebMD Problem | Market | Company | Product| Business Plan | Development| Finances

Market CDC estimates 7.2mil high school athletes in the US 1 NCAA comprises 400,000+ athletes 700+ men’s and 500+ women’s soccer teams total FIFA estimates 265mil people play soccer worldwide 2 In soccer, 70% of all ACL injuries are non-contact 3 UEFA’s top 25 teams have an operating income of over $1 billion and revenue of $7 billion in CDC: MMWR; September 29, 2006 / 55(38); ; 2.A Junge; J Dvorak; Br J Sports Med : i3-i7; doi: /bjsm Katharina Grimm, MD; Holly Silver, PT; Bert Mandelbaum, MD; Health and Fitness for the Female Football Player ; Problem | Market | Company | Product| Business Plan | Development| Finances

Wearable during athletic movements Massive database ProKnee The ProKnee Advantage Mechanical and Physiological Modeling Wearable during athletic movements Massive database Mechanical or Physiological Modeling Laboratory based movements Small scale data collection Problem | Market | Company | Product| Business Plan | Development| Finances

Design Problem | Market | Company | Product| Business Plan | Development| Finances

Design – Insole Attachment  Gyroscope/Accelerometer Work together to give position to calculate ankle angle  Wire Connects to knee straps for power and to relay data  Force Sensors Force summed to find moment at knee at impact Determines time of impact Problem | Market | Company | Product| Business Plan | Development| Finances

Design – Knee Straps Problem | Market | Company | Product| Business Plan | Development| Finances  Gyroscope/Accelerometer Work together to give position to calculate flexion angle and medial motion angle  EMG (VL-ST) Measures muscle activation  Wire Connects to hip pack for power electronics and relay data

Design – Hip Pack  Battery (9V) Power electronics in unit  USB Memory (1 GB) Stores data for use with software later  Gyroscope/Accelerometer Work together to give position and angle of torso  Wire Connects to knee straps to power electronics and receive information Problem | Market | Company | Product| Business Plan | Development| Finances

Design Problem | Market | Company | Product| Business Plan | Development| Finances

Business Model Phase 1: Prototyping Proof of concept Initial working prototype and testing Fundraising Venture Capitalists SBIR Phase 2: Research and Development Distribute to select athletic teams and collect data Proof of concept: able to identify individuals at risk build consumer confidence in our product Strategic Partnerships Researchers Military Sports teams and industry Problem | Market | Company | Product| Business Plan | Development| Finances

Business Model (cont.) Phase 3: Initial Product Release Target athletic teams, gyms, and physical therapists. Data will be collected and sent to our company for analysis. Projected cost: $250 initial startup fee $50 per athlete per analysis Phase 4: Review and Expansion Product will be reviewed and updated. Researchers will be able to subscribe to our database. Expansion to improve technical support and increase sales representatives. Ultimately targeting individuals for home use. Problem | Market | Company | Product| Business Plan | Development| Finances

Phase I  Prototype 1 – Accurately model knee movement: Test 1: Differentiate between people Test 2: Differentiate between motions of an individual  Prototype 2 – Portable enough for athletic use Maintain accuracy and repeatability  Display movements and muscle firing in a computer model 61830Months: 0 Phase I Phase IIIPhase IIPhase IV Problem | Market | Company | Product| Business Plan | Development| Finances

Phase II  Apply for FDA approval and patent  License to industry and academia  Clinical Trials 1 (Predictive) Phase III  Clinical Trials 2 (Preventative)  Market to sports teams  1 st generation release Phase IV  Review data for 2 nd generation release 61830Months: 0 Phase I Phase IIIPhase IIPhase IV Problem | Market | Company | Product| Business Plan | Development| Finances

Phase I Budget Part and ID#NotesSourceQuantityUnit PriceSubtotal MEMS Gyroscope ( ND)DUAL AXIS 16-LGA ±300°/sDigikey MEMS Gyroscope (ADXRS612BBGZ-RLCT-ND)IC SENSOR GYRO 7MV 250D/S 32CBGADigikey MEMS Accelerometer ( ND)±2g, 8g; 3-axis; Analog OutDigikey MEMS Accelerometer ( ND)±2g, 8g; 3-axis; Analog Out; Shock ResistantDigikey Wii Motion Plus (Gyroscope Attachment)Keith's SuggestionNintendo Wiimote1 borrowed, 1 purchased Knee braceBorrowedAmazon.com Arduino microcontrollerBorrowedArduino20.00 EMG AmplifierLafayette EMG AmplifierGetThatPart OscilloscopeBorrowed NIDAQ USBMultiple inputs, so A/D converters neededBorrowed Computer with MATLAB software Borrowed10.00 Batteries Large EKG/EMG contact pads ECG electrodes Total Problem | Market | Company | Product| Business Plan | Development| Finances

Financial Projections Phase I Phase IIIPhase IIPhase IV Problem | Market | Company | Product| Business Plan | Development| Finances

Thank you Dr. Paul Sadja Associate Professor of Biomedical Engineering Jim Gossett Associate Athletics Director for Sports Medicine Paige Plash Physical Therapist, COO Encore Rehabilitation Dr. Elizabeth Hillman Assistant Professor of Biomedical Engineering Keith Yeager Senior Staff Associate, Laboratory Manager

Questions?