PureHeart TM Barry W. Ritz, PhD Institute for Functional Medicine May 30, 2013

Screening + Supplements = Success TM

“Beyond Lipids” Underlying factors Lipid balance Blood flow, vascular function CoQ10 status Glucose metabolism Oxidative stress Co-support Medications Supplements Lifestyle

Cleveland HeartLab Roadmap Step 1Step 2Step 3 Contact Cleveland HeartLab® Determine Clinical Goals -algorithms Choose from Pure Encapsulations® Supplements Retest after 3-6 months

Step 1Step 2Step 3 Contact Cleveland HeartLab® Determine Clinical Goals Choose from Pure Encapsulations® Supplements Myeloperoxidase (MPO): Proprietary marker for arterial wall health. ≥ 480 pmol/L Support healthy glucose metabolism* Alpha Lipoic Acid w/Glucophenol TM, Metabolic Xtra Support healthy CoQ 10 levels* SR-CoQ 10 w/PQQ or Ubiquinol VESIsorb ® Support antioxidant defense* ResCu-SR TM or Resveratrol VESIsorb ® *These statements have not been reviewed by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Cleveland HeartLab Roadmap

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Pure Encapsulations ® Supplements Research-based Professionally dosed Hypoallergenic Formulated for sensitive individuals Avoiding: Common allergens, coatings, shellacs, binders, fillers, excipients, artificial flavors, artificial sweeteners, or colors

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy glucose metabolism* Berberine HCl, alpha-lipoic acid, resVida (trans- resveratrol), Zychome (Cr dinicocysteinate) Insulin receptor function (AMPK, SIRT1) and glucose homeostasis* Metabolic Xtra

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy glucose metabolism* Alpha Lipoic Acid w/ Glucophenol Insulin sensitivity and glucose clearance*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy glucose metabolism* * * Glucose Uptake Inflammation Response

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy CoQ 10 levels* Microactive ® slow release CoQ10 PQQ (pyrroloquinoline quinone) Complementary mechanisms in cardioprotection and cognitive/neuronal health* Extended Release Plasma CoQ10 (mcg/mL) SR-CoQ 10 with PQQ

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy CoQ 10 levels* Ubiquinol- Active antioxidant form of CoQ10 Self-assembling colloidal delivery system for maximum absorption Ubiquinol VESIsorb

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Healthy CoQ 10 levels*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Antioxidant defense* Microactive® high bioavailability, sustained release resveratrol and curcumin- consistent delivery Exclusive, proprietary formula ResCu-SR TM Resveratrol Curcumin

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Antioxidant defense* Payette C et al. Sex differences in postprandial plasma tumor necrosis factor-α, interleukin-6, and C-reactive protein concentrations. Metab Clin Exp (2009) 58: ResCu-SR TM

Screening + Supplements = Success TM Easy as Please visit our microsite for more information ResCu-SR