Thermo Scientific Konelab 20XT and Konelab 20

Fully automated Konelab systems Compact and proven analyzers Easy and cost-efficient to use Konelab 20: Capacity up to 200 tests/hour For routine clinical chemistry testing Konelab 20XT: Capacity up to 250 tests/hour For routine and esoteric clinical chemistry testing

Product overview Continuous access to samples, reagents and cuvettes Konelab 20 Konelab 20XT Capacity up to 200 tests/hr up to 250 tests/hr ISE option Na+, K+, Cl-, Li+ TDM/DAT No Yes Sample positions Up to 84 on-board, 5 STAT samples Reagent positions 35 cooled Cuvette storage positions 600 Mixing Needle mixing Separate mixing paddle Continuous access to samples, reagents and cuvettes

Wide test range - with user-defined application flexibility CE marked, bar coded system reagents Enzymes and substrates Electrolytes Specific Proteins Drugs of Abuse Tests in the model 20XT Therapeutic Drug Monitoring in the model 20XT Over 80 carefully validated methods according to IFCC and other widely used recommendations Can easily be complemented by user definable applications Special applications to be validated by the customer or distributor

Flexible, automated operation Possibility for up to 4 reagent additions per test Automated sample pretreatment feature Versatile dilution features Pre-dilution possibility Post-dilution with both high and low secondary dilution ratios Calibrator set made automatically from one stock calibrator for most specific proteins Different sample types can be analysed at the same time Important in drug monitoring and therapeutic control Reflex testing Saves time and money when finding out the specific test to be run E.g. A patient is having a severe chest pain and you don’t know if s/he is having acute myocardial infarction or not. There is no point of running lots of expensive tests if the basic test is negative. Reflex testing in Konelab can be programmed so that if the creatine basic test is within a normal range then no more tests have to be run, but if it is elevated then the system runs a more specific test.

Productive, accurate analysis User-safe and contamination free measurement Proven, unique, single use 12-cell cuvette Cost-effective due to low reaction volume Only 100 to 250 l Typically 120 - 200 l Flexibility and long walk-away time Cuvette storage enables up to 2.5 hours walk-away time Continuous loading access without interrupting testing

Bright graphical user-interface Advanced fully graphical user-interface Provides fast guidance Makes the analyser easy to use Available in more than 20 language versions Back-up possibilities On hard disk On CD/ USB

Safe sample handling Error free sample handling Automatic sample identification, direct barcode reading and cup/ tube recognition Bidirectional LIS interface for quick data transfer Continuous sample loading Sample tubes 5, 7 and 10 ml tubes 0.5 and 2 ml sample cups

Sample disk 84 samples, calibrators and controls on board 6 segments, 14 pos. in each segment 5 dedicated urgent (STAT) positions Possibility to load also into segments

Automated sample pretreatment Saves the operator time, e.g. by automating hemolyzation in HbA1c measurement Improves quality by minimizing operator variation Dedicated sample segment for whole blood samples For one segment hemolyzation takes about 10 min, total turnaround time about 30 min

Convenient reagent handling Reagents can be added at any time Continuous monitoring possibility Flagging of expired reagents Determination of vial volume Estimation of reagent sufficiency Automatic bottle change-over increases the walk-away time Possibility to run QC with every new bottle Used reagent lots can be archived

Reagent disk 35 vial positions External barcode reader Cooled disk

Simultaneous electrolyte measurement Direct measurement method used in Konelab Generally considered the most accurate ISE method Serum, plasma and urine samples Direct or by manually pre-diluted urine sample Micro volume electrodes for even smaller sample volumes Sample volume of only 50 l is sufficient for Na+, K+ and Cl- Additionally 6 l if Li+ is required Maintenance-free electrodes Delivered ready-to-use

Minimal maintenance - no water supply or drainage requirements Daily – 5 min Fill distilled water, empty waste water container Empty cuvette waste compartment Perform Start up and Stand by procedures Check the bag of ISE Calibrator solution 1 6 months maintenance Change diluent/ wash tubes Change the lamp 12 months maintenance Change the syringe Change the dispensing needle Change the mixing paddle in 20XT Change drain/ waste tubes

Technical and application expertise all the way Konelab analyzers are supported with Customized installation Product training Product & Application support After-sales support Maintenance contracts Technical service

Fulfilling requirements Quality system is certified according to the ISO 9001:2000 standard extended with the EN ISO 13485:2003 Konelab systems are compliant with the requirements of the In Vitro Diagnostic Medical Device Directive (IVDMDD)

Key benefits of Konelab analyzers Easy to use Clearly laid out, simple to navigate user interface Automation and analyst efficiency Once loaded, the analyzer will run without the assistance of the analyst Automatic dilution of an over range sample Automated sample pretreatment feature Reflex test possibility Different types of samples can be analysed at the same time Important in drug monitoring and therapeutic control User-safe and contamination free analysis Disposable cuvettes Productivity Low reagent volumes -> low cost per test, important in expensive tests Quick daily start up Minimal maintenance

Key benefits of Konelab analyzers Carefully selected methods and applications Over 150 CE-marked reagents Optimized kits serve different-sized laboratories Ready for use, stable liquids System-specific multi-calibrators and controls Flexible software Easy method set-up Special applications to be validated by the customer or distributor Direct electrolyte measurement The most accurate ISE method Maintenance-free electrodes delivered ready-to-use Full application and technical support

One reagent line to be used in all Konelab analyzers Albumin ACP Total and Direct Bilirubin ALP Carbon Dioxide ALT/GPT Calcium AST/GOT Cholesterol Amylase HDL and LDL Cholesterol Cholinesterase Creatinine Dibucaine Glucose CK Iron CK-MB Magnesium Gamma-GT Phosphorus -HBDH Total Protein LDH Triglycerides Lipase U/CSF Protein Urea Uric Acid Na, K, Cl Ca, pH Albumin Antistreptolysin O  -1-Antitrypsin Apolipoprotein A1 and B Ceruloplasmin Complement C3 and C4 C-reactive protein Cystatin C High Sensitive CRP HbA1c Haptoglobin IgA, G and M Lipoprotein (a) Microalbuminuria Myoglobin Orosomucoid Prealbumin Rheumatoid factors Transferrin Amphetamine Barbiturates Benzodiazepines Cannabinoids Cocaine Metabolite Opiates Cotinine Ethyl Alcohol Methadone Propoxyphene Carbamazepine Phenobarbital Phenytoin Theophylline Valproic Acid Lithium Enzymes Substrates DoA (DAT) Specific Proteins TDM Electrolytes

Konelab 20XT and Konelab 20 For convenient and precise clinical chemistry analysis!