Synthetic route Start with: To make: USING A GRIGNARD REACTION!

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Presentation transcript:

Synthetic route Start with: To make: USING A GRIGNARD REACTION!

Clickers: which sequence would be a workable route to the required Grignard reagent? A: B: C:

Clickers: which sequence would be a workable route to the required Grignard reagent? A: B: C:

Clickers: Which is the best electrophile to use?

Clickers: Which is the best electrophile to use?

Clickers: What reagent(s) would be best for the last step? A:KOtBu, tBuOH B:H 2, Pd, MeOH C:H 2 SO 4 (aq.) D:Zn(Hg), HCl

Clickers: What reagent(s) would be best for the last step? A:KOtBu, tBuOH B:H 2, Pd, MeOH C:H 2 SO 4 (aq.) D:Zn(Hg), HCl