Jwanro Hassan,Marc Se′ vignon,Christel Gozzi,Emmanuelle Schulz,and arc Lemaire*, Laboratoire de Catalyse et Synthe` se Organique, UMR 5622, Universite′

Slides:

Advertisements

Similar presentations

Genealogies of time structured data, an application on cave bear ancient DNA Frantz Depaulis Ludovic Orlando Catherine Hannï UMR 5534 Centre de Génétique.

Advertisements

Electrophilic Reaction on Nitrogen R = H: pKa 5,23pKa pKa 6.95.

Iron-catalyzed Cross Coupling reactions: From Rust to a Rising Star

Carbon Nucleophiles : Organometallics of Li, Mg etc. 1. Cyanide :Well known 1 carbon unit 2. Acetylides :pKa = 25 Requires polar solvent to solubilize.

Oxidative Coupling Scott Dufour.

Iron Catalyzed Cross-Coupling Reaction: Recent Advances and Primary Mechanism Wang Chao

Alcohols: Structure & Synthesis

Amines.  Amines are formed by replacing one or more hydrogen atoms of ammonia (NH 3 ) with alkyl groups.  In nature, they occur among proteins, vitamins,

Reporter: Yu Ting Huang Advising Prof: Ru Jong Jeng 1.

Low valent of Vanadium catalyst in organic synthesis.

Year 3 CH3E4 notes: Asymmetric Catalysis, Prof Martin Wills

John E. McMurry Paul D. Adams University of Arkansas Chapter 10 Organohalides.

CHEMISTRY OF BENZENE: ELECTROPHILIC AROMATIC SUBSTITUTION Dr. Sheppard CHEM 2412 Summer 2015 Klein (2 nd ed.) sections: 19.1, 19.2, 19.3, 19.4, 19.5, 19.6,

 The limited Reagent is the reactant in a chemical reaction that limits the amount of product that can be formed.  The molecule that produces the least.

Palladium Catalyzed C-N Bond Formation Jenny McCahill

1 Substitution Reactions of Benzene and Its Derivatives: Electrophilic Addition/Elimination Reactions. Benzene is aromatic: a cyclic conjugated compound.

16. Chemistry of Benzene: Electrophilic Aromatic Substitution

Chapter 8 Alkenes: Reactions and Synthesis.  Alkenes react with many electrophiles to give useful products by addition (often through special reagents)

Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination Elisabeth T. Hennessy & Theodore A. Betley* Science 2013, 340, 591 Also featured.

Chapter 13: Aldehydes and Ketones

Very Weak Acid Ionization Constants CH 3 COCH 2 COCH 3 CH 3 NO 2 H 2 O C 2 H 5 OH CH 3 COCH 3 RCCH RCH=CH 2 CH 3 CH 3 COCH - COCH 3 CH 2 – NO 2 OH – C.

Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as.

14.11 Alkane Synthesis Using Organocopper Reagents

Objective. Reactions of Haloarenes with metals When the magnesium metal reacts with bromobenzene and iodobenzene in presence of ether to form Grignard.

Speaker: Chien-An Chen Teacher: Guey-Sheng Liou

Ethers Nanoplasmonic Research Group Organic Chemistry Chapter 8 Part I.

Chapter 7. Alkenes: Reactions and Synthesis. 2 Diverse Reactions of Alkenes Alkenes react with many electrophiles to give useful products by addition.

7. Alkenes: Reactions and Synthesis

A Green Chemistry Module Nucleophilic Aromatic Substitution Presidential Green Chemistry Challenge Award Elimination of Chlorine in the Synthesis of 4-Aminodiphenylamine.

ALKENE AND ALKYNE REACTIONS, CONTINUED Dr. Clower CHEM 2411 Spring 2014 McMurry (8 th ed.) sections , , , , 8.10, 8.12,

High-Oxidation-State Palladium Catalysis 报告人：刘槟 2010 年 10 月 23 日.

John E. McMurry Paul D. Adams University of Arkansas Chapter 10 Organohalides.

Organometallic Compounds

Spring 2011Dr. Halligan CHM 236 Organometallic Compounds Chapter 11.

Ethers and Epoxides Chem. 108 Chapter 8 1. Ether is a class of organic compounds that contain an ether group R–O–R. For the simplest ether, Dimethyl ether.

CH 7: Alkenes, Reactions and Synthesis

IV. Oxidation Three types A. Epoxidation B. Hydroxylation C. Oxidative cleavage.

14.11 Alkane Synthesis Using Organocopper Reagents

Redox Relay Heck Reaction

CH 7: Alkenes, Reactions and Synthesis

SILICONES AND PHOSPHAZENES. Silicones and phosphazenes are examples of inorganic Polymers. Inorganic elements can have different valencies Than carbon.

Recycling the Waste: The Development of a Catalytic Wittig Reaction Angew. Chem. Int. Ed. 2009, 48, 6836 –6839.

Indium in Organic Synthesis Huang-Jianzhou

Table 15-1, p Common Names of Carboxylic Acids Table 15.1.

Chapter 12: Alcohols from Carbonyl Compounds CH 12-1 Alcohol RedOx Oxidation (loss of H) of alcohols to form carbonyls Reduction (gain of H) of carbonyls.

Chapter 24. Amines Based on McMurry’s Organic Chemistry, 6 th edition.

1 C-H Arylation: An Efficient & Sustainable Synthesis of π-Conjugated Organic Electronic Materials Aiman Rahmanudin Laboratory for Molecular Engineering.

Preparation of Alkanes Methane through -pentane and iso-pentane can be obtained in pure form by fractional distillation of petroleum and natural gas; neo-pentane.

CHAPTER 7: REACTION MECHANISMS CHEM171 – Lecture Series Seven : 2012/01 Reaction mechanisms involve the movement of electrons 1-electron 2-electrons BOND.

PHR 301: MEDICINAL CHEMISTRY 1 Lecture 3. C=C Double Bond (sp2 hybridized orbitals)

SOFTWARE: A SOLUTION FOR MODEL PREDICTIVE CONTROL SOFTWARE: A SOLUTION FOR MODEL PREDICTIVE CONTROL Laboratoire.

© 2016 Cengage Learning. All Rights Reserved. John E. McMurry Chapter 10 Organohalides.

Organic Halogen Compounds

 Welcome .

Conjugated Organic Materials

J. Perron,a B. Joseph,b J.-Y. Méroura

Organic halides.

Chapter 10 Organohalides

Jeopardy Hosted by Chem Istry.

الاحتراق.

Cu Catalyzed Cross Coupling

Chapter 3 Adel M. Awadallah Islamic University of Gaza

Five Slides about Concurrent Tandem Catalysis

Organic Halogen Compounds

Chemistry of Benzene: Electrophilic Aromatic Substitution

Preparation Reactions of Alkanes

Radically “Green” Approaches to Hydrocarbon Functionalization via Allyl Transfer This research involves the development and application of a recently discovered.

Radically “Green” Approaches to Hydrocarbon Functionalization via Allyl Transfer This research involves the development and application of a recently discovered.

Catalytic Enantio- and Diastereoselective Allylations with Nucleophilic p-Allylpalladium Complexes Elizabeth R. Jarvo, Department of Chemistry, University.

Presentation transcript:

Jwanro Hassan,Marc Se′ vignon,Christel Gozzi,Emmanuelle Schulz,and arc Lemaire*, Laboratoire de Catalyse et Synthe` se Organique, UMR 5622, Universite′ Claude Bernard Lyon 1, CPE, 43 Bd du 11 Novembre 1918, Villeurbanne Cedex, France, and Laboratoire de Catalyse Moleculaire, UPRESA,CNRS 8075, Institut de Chimie Mole′ culaire d’Orsay,Universite′ Paris-Sud, Orsay Cedex, France Aryl-Aryl Bond Formation Chem. Rev. 2002, 102,

The first type is the Ullmann reaction. The third type is clearly an oxidation of two C-H aromatic bonds to form a C-C bond. The second type is closely related to the first but involves the formation of an aryl carbanion as the intermediate. The fourth type and last one is the Pschorr reaction.

1. Aryl Aryl Bond Formation Using Copper as Reagent or Catalyst 1.1. Reductive Coupling of Aromatic Halides (The Ullmann Reaction) A. Aromatic Coupling Using Stoichiometric Amount of Copper a. Symmetrical Couplings.

b. Unsymmetrical Couplings.

B. Aromatic Coupling Using Catalytic Amounts of Copper

1.2. Coupling of Aromatics via Aryl Carbanion A. Use of Stoichiometric Amounts of Copper a. Symmetrical Couplings. i. Coupling of Silicon Derivatives.

ii. Coupling of Tin Derivatives.

b. Unsymmetrical Couplings. i. Coupling of Silicon Derivatives.

ii. Coupling of Lithium Derivatives.

B. Catalytic Amounts of Copper a. Symmetrical Couplings. i. Coupling of Silicon Derivatives. ii. Coupling of Tin Derivatives.

b. Unsymmetrical Couplings. i. Coupling of Tin Derivatives. ii. Coupling of Boron Derivatives.

1.3. Oxidative Aromatic Coupling Using Copper Salts A. Use of Stoichiometric Amount of Copper a. Symmetrical Couplings.

b. Unsymmetrical Couplings.

B. Use of Catalytic Amounts of Copper a. Symmetrical Couplings.

b. Unsymmetrical Couplings.

c. Oxidative Coupling with FeCl3.

4. Aromatic Coupling via Radicals (The Pschorr Reaction) Using Copper Salts

1.5. Synthesis of Oligomers and Polymers Using Copper as a Reagent A. The Ullmann Reaction

B. Oxidative Coupling of an Activated Aryl a. Using Copper as the Oxidative Reagent.

b. Using Iron as the Oxidative Reagent.

C. Chemical Polymerization Induced by Iron