WP1 Progress report Vienna, 13 March 2011

Achievements General -4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place -Obtained approval from Medicines and Healthcare products Regulatory Agency -Local Ethical Approval obtained provisionally, pending clarifications

Achievements Structural Imaging  Site survey ✔  Site selection ✔  Radiological and structural protocols (ADNI-GO) for 3T scanners finalised and Manual sent to sites ✔  Image Management System (TrialTracker) and electronic data transfer tool (TrialWire) ✔  Sites to upload protocol and return protocol form in progress  Sites to scan phantom and send details to IXICO in progress  Sites to scan 1 healthy volunteer and send details to IXICO not started Qualification and start scanning

Achievements Structural Imaging 3T SITE Survey Sent Survey Received Protocol Sent Protocol Received ACR Phantom at Site ACR Phantom Scan Requested ACR Phantom Scan Received LondonYYYYYYY PragueYYYYYYY LeuvenYYYYYYY UtrechtYYYYYYN MelbourneYYYYYYN CopenhagenYYYYYYN Tel AvivYYYYYYN MadridYYYYNNN NaplesYYYNNNN BucharestYYYNNNN Innsbruck considering to join WP1

Achievements Magnetic Resonance Spectroscopy  London, Copenhagen, Utrecht have met and agreed protocol  Spectra (anterior cingulate and thalamus) from Copenhagen and Utrecht can be read and give reasonable values  The data can provide metabolite ratios  Currently exploring whether we can do correction for CSF in the MRS voxel which is a superior approach to the ratio method

Milestones 1Completion of preparation work for MRI sites 2Start scanning Deliverables 1Qualification of sites, test of electronic data transfer tool 2 Estimate of numbers (200 in total: if 10 sites, 20 patients per site)

Possible concerns Combination of MRS data: - Existing power calculation did not take into account the greater variability of multicentre design - Increase number of subjects with MRS at each site (~30-40 each: existing plan is for 20 subjects scanned twice in London and Copenhagen, so it would be slightly more than double) - If datasets cannot be combined, we could explore whether findings are reproduced across sites

Planned progress -Obtain final approval from local ethics -Qualify sites -Start recruitment and scanning -All sites to continue to scan phantom regularly plus 2 healthy volunteers (from the site) yearly, preferably every 6 months and before and after upgrades