Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): Urinary Screening and Baseline Biochemical and Cardiovascular Assessments Featured Article: M. Loredana Marcovecchio, John Woodside, Timothy Jones, Denis Daneman, Andrew Neil, Toby Prevost, R. Neil Dalton, John Deanfield, and David B. Dunger, on behalf of the AdDIT Investigators Diabetes Care Volume 37: March, 2014

STUDY OBJECTIVE To assess the association between early increases in albumin excretion and cardiovascular (CV) and renal markers in a large cohort of young people with type 1 diabetes Marcovecchio L. M. et al. Diabetes Care 2014;37:

STUDY DESIGN AND METHODS In a preliminary screening for a multicenter, randomized controlled trial of statins/ACE inhibitors, albumin–creatinine ratio (ACR) was measured in six early-morning urine samples from 3,353 adolescents Tertiles were calculated based on an established algorithm From higher-risk subjects (upper ACR tertile), 400 were recruited into the intervention study (trial cohort) From lower-risk subjects (middle–lower ACR tertiles), 329 were recruited into the observation cohort At baseline, vascular measurements, renal markers, and CV disease markers were assessed Marcovecchio L. M. et al. Diabetes Care 2014;37:

RESULTS Age- and sex-adjusted pulse wave velocity was higher in the trial than in the observational cohort Non-HDL cholesterol and apolipoprotein (Apo)B–ApoA-1 ratio were higher in the trial cohort Cystatin C and creatinine were decreased Estimated glomerular filtration rate increased in the trial compared with the observational cohort Marcovecchio L. M. et al. Diabetes Care 2014;37:

CONCLUSIONS In adolescents with type 1 diabetes, the group with the highest tertile of albumin excretion showed more evidence of early renal and CV disease than those in the lower tertiles Marcovecchio L. M. et al. Diabetes Care 2014;37: