Gene SymbolGene DescriptionFold Lna21-SP21-S RP2retinitis pigmentosa 2 (X-linked recessive)1.3-1.6 DDAH1dimethylarginine dimethylaminohydrolase 11.4-1.5.

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Gene SymbolGene DescriptionFold Lna21-SP21-S RP2retinitis pigmentosa 2 (X-linked recessive) DDAH1dimethylarginine dimethylaminohydrolase PM20D2peptidase M20 domain containing RAD51AP1RAD51 associated protein PAG1 phosphoprotein associated with glycosphingolipid microdomains ENPP1ectonucleotide pyrophosphatase/phosphodiesterase FAM36Afamily with sequence similarity 36, member A FAM3Cfamily with sequence similarity 3, member C CCNG1cyclin G FAM3Cfamily with sequence similarity 3, member C ALG10B asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase) APAF1apoptotic peptidase activating factor MAMLD1mastermind-like domain containing ARHGAP19Rho GTPase activating protein ZNF826zinc finger protein RNF103ring finger protein SLC17A5 solute carrier family 17 (anion/sugar transporter), member CEP97centrosomal protein 97kDa LEPREL1leprecan-like SASS6spindle assembly 6 homolog (C. elegans) ZDHHC2zinc finger, DHHC-type containing PRTFDC1phosphoribosyl transferase domain containing FOXN3forkhead box N CCR7chemokine (C-C motif) receptor E2F3E2F transcription factor C9orf100chromosome 9 open reading frame IL1RAPinterleukin 1 receptor accessory protein BVESblood vessel epicardial substance FAM13A1family with sequence similarity 13, member A SGEF Src homology 3 domain-containing guanine nucleotide exchange factor NCAPD3non-SMC condensin II complex, subunit D FAM63Bfamily with sequence similarity 63, member B PRICKLE2prickle homolog 2 (Drosophila) COL4A1collagen, type IV, alpha RBMS3RNA binding motif, single stranded interacting protein KIAA PSRC1proline/serine-rich coiled-coil MORC4MORC family CW-type zinc finger Table S2: List of Additional predicted targets based on overexpression and knockdown of miR-21 in keratinocytes

Gene SymbolGene DescriptionFold Lna21-SP21-S TGFBR2transforming growth factor, beta receptor II (70/80kDa) E2F8E2F transcription factor KLHL15kelch-like 15 (Drosophila) C4orf21chromosome 4 open reading frame C1orf112chromosome 1 open reading frame DNAJC19DnaJ (Hsp40) homolog, subfamily C, member IL12RB2interleukin 12 receptor, beta LRRCC1leucine rich repeat and coiled-coil domain containing TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa DZIP3DAZ interacting protein 3, zinc finger ORC3Lorigin recognition complex, subunit 3-like (yeast) SGOL2shugoshin-like 2 (S. pombe) FBXO9F-box protein WDR67WD repeat domain NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif ALG6 asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase) FAM73Afamily with sequence similarity 73, member A ZNF507zinc finger protein KIF14kinesin family member HMMRhyaluronan-mediated motility receptor (RHAMM) TMEM19transmembrane protein LHFPlipoma HMGIC fusion partner RPGRIP1LRPGRIP1-like GTSE1G-2 and S-phase expressed CA13carbonic anhydrase XIII CKAP2cytoskeleton associated protein TBC1D19TBC1 domain family, member TMEM14Atransmembrane protein 14A ARID2AT rich interactive domain 2 (ARID, RFX-like) WDR7WD repeat domain SETMARSET domain and mariner transposase fusion gene PRKD3protein kinase D Table S2: List of Additional predicted targets based on overexpression and knockdown of miR-21 in keratinocytes