Oxford Street 2 progress update Paul Cullinan NHLI: Fan Chung/Rudy Sinharay/Peter Collins KCL: Ben Bradshaw et al. Exposomics November 2014.

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Presentation transcript:

Oxford Street 2 progress update Paul Cullinan NHLI: Fan Chung/Rudy Sinharay/Peter Collins KCL: Ben Bradshaw et al. Exposomics November 2014

Boris Johnson admits London's Oxford Street is one of world's most polluted London mayor makes u-turn over Oxford Street’s pollution levels in a letter to the EAC about research funding for King’s College, that made the original claim on air quality. 13 Nov comments

cross-over design 40 each: COPD (moderate) IHD (stable, no COPD) Healthy (neither of above)

Schedule of measurements time re. exposure-2hr0hr+1hr+2hr+3hr+4hr+24h placelab.site lab. time8am10am11amnoon1pm2pm3pm4pmnoon symptomsXX X X XX arterial stiffnessX XX XX continuous ECG X venesectionX XX urine collectionX X spirometryXXXXX XXX ios X X EB condensateX X X induced sputumX clinical measurements

pre-exposure questionnaires: geography postcodes home work significant other today’s date how did you get here today? tube( ) bus( ) car( ) motorbike( ) bicycle( ) walk( ) Where were you? (tick one or more) home ( )work ( ) significant other ( ) any other? (describe) yesterday

pre-exposure questionnaires: diet breakfastlunchsupperother yesterday time place food and drink today time place food and drink tomorrow time blank place food and drink

exposures (n=c.120 measurements) Hyde Park Oxford Street P median distance walked5.3mi temp >.05 RH >.05 noise <0.001 PM < PM < ultrafine n < carbon black <0.0001

male N ageFEV 1 % pred FVC % pred PWV m/s AI % IOS 5Hz kPa/L/s COPD IHD healthy participants

healthyCOPDIHD FEV 1

healthyCOPDIHD impulse oscillometry (5Hz)

healthyCOPDIHD AI

Next steps samples to labs ‘exposomic’ questionnaire information analysis …