Diphtheria toxin deconstruction Motivos: módulos simples de combinaciones de estructura secundaria ( a veces se asocian a una función) Dominios: agrupación.

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Presentation transcript:

Diphtheria toxin deconstruction

Motivos: módulos simples de combinaciones de estructura secundaria ( a veces se asocian a una función) Dominios: agrupación de motivos de plegado característico (pueden o no ser unidades de plegado autónomo; pueden o no estar asociados a una función) Estructura terciaria: combinación de dominios

Tipos de dominios alfa beta alfa+beta alfa/beta

Motivo: alfa-loop-alfa

Figure 17: The complexation of calcium in EF hands

Conservation of calcium binding loop in EF-hand motifs

Figure 24: Effects of calcium binding of the structure of the EF-hand domain of spectrin

CRO repressor Motivo: alfa-turn-alfa

trp repressor

Leucin_rich repeat

Human growth hormone Dominio manojo de hélices

Dominio globina

myoglobin Dominio globina

Motivo beta hairpin

streptococcal protein G

HLA DQ, una molécula del MHC

Porine

Motivo beta-alfa-beta

TIM barrel:closed Rosmann fold

fosforibosil antranilato isomerasa +indol glicerol fosfato sintasa

Flavodoxina: open Rossman fold

Class Number of foldsNumber of superfamiliesNumber of families All alpha proteins All beta proteins Alpha and beta proteins (a/b) Alpha and beta proteins (a+b) Multi-domain proteins40 55 Membrane and cell surface proteins Small proteins Total SCOP: Structural Classification of Proteins release PDB Entries (15 May 2004) Domains. 1 Literature Reference (excluding nucleic acids and theoretical models)

Thanks Alberto Podjarny Ermacora