115/13/2015 B Cell Maturation, Activation & Differentiation Hugh B. Fackrell Jan 4,1998.

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Presentation transcript:

115/13/2015 B Cell Maturation, Activation & Differentiation Hugh B. Fackrell Jan 4,1998

225/13/2015 B Cell Maturation, Activation & Differentiation l Assigned Reading l Content Outline l Performance Ojectives –Key terms –Key Concepts l Short Answer Questions

335/13/2015 Assigned Reading l Chapter: 8 pp l Janis Kuby’s Immunology 3rd Ed

445/13/2015 Content Outline l B Cell Maturation l B Cell Activation & Proliferation l In Vivo induction of Humoral Response l B Cell Differentation l Regulation of B Cell Development

555/13/2015 B Cell Maturation l Bone marrow l Ig Gene rearrangements l Pre B cell receptor l Selection of Immature Self Reactive B Cells –negative selection –rescue editing of light chain genes

665/13/2015 B Cell Activation & Proliferation l T dependent vs T independent antigens l Origins of activating signals l Transduction of Activating signals l B cell coreceptor complex l T helper cells –formation of T-B conjugate –mediation by CD40 –induction of progression signals l Negative selection

775/13/2015 In Vivo Induction of Humoral Response

885/13/2015 B Cell Differentation l Affinity maturation –somatic hypermutation – antigen selection l Class switching l Plasma cells l Memory cells

995/13/2015 Regulation of B Cell Development

10 5/13/2015 Performance Objectives

11 5/13/2015 Key Terms l affinity maturation, apotosis, avidity, capping, carrier effect, cell mediated immunity,Cytotoxic T cells, Helper T cells, TH1 cells, TH2 cells, humoral immunity, immunologic memory, perforin, plasma cells, primary antibody, programmed cell death, secondary antibody, thymus dependent antigens, thymus independent antigens

12 5/13/2015 Key Concepts l Describe the sequential development of the humoral immune response. l Draw a contemporary model for T cell B cell macrophage interaction l Describe antigen processing and presentation by B cells

13 5/13/2015 l Outline the sequence of helper (T/(TH) cell involvment in antibody production l Describe the interplay between TH1 and Th2 cells in the development of immune responses

14 5/13/2015 Short Answer Questions

15 5/13/2015 DONE!!!