Siva Arunasalam, M.D. High Desert Heart Institute

ProArgi-9+ Active HDHI Study 9 Healthy Subjects + Dan Austin 9 Healthy Subjects + Dan Austin Ages: d60an Ages: d60an

ProArgi-9+ Active HDHI Study Measure lactic acid levels during vigorous exercise Measure lactic acid levels during vigorous exercise Lactic acid accumulates when body goes into oxygen debt Lactic acid accumulates when body goes into oxygen debt More vigorous the exercise the longer the duration of exercise, higher the lactic acid accumulation More vigorous the exercise the longer the duration of exercise, higher the lactic acid accumulation Lactic Acid causes muscle fatigue Lactic Acid causes muscle fatigue Lactic acid accumulation decreases muscle performance Lactic acid accumulation decreases muscle performance

ProArgi-9+ Active HDHI Study Hypothesis: If L-Arginine increases muscle blood flow, then there will be less lactic acid accumulation. Thus increasing endurance & muscle recovery.

ProArgi-9+ Active Formulation Blocks oxidation of LDL cholesterol Blocks oxidation of LDL cholesterol Multiple studies performed with mg. with benefits including helping maintain BP already in normal range Multiple studies performed with mg. with benefits including helping maintain BP already in normal range Ingredients of PA9Active have more than 200mg. per serving of Quercetin Ingredients of PA9Active have more than 200mg. per serving of Quercetin Protection: Antioxidant against factors such as oxidative stress, radiation, cell damage Protection: Antioxidant against factors such as oxidative stress, radiation, cell damage Quercetin: Broad Spectrum Protection

Quercetin Mechanism of Action Free Radical scavenger (Antioxidant) Free Radical scavenger (Antioxidant) Promotes a healthy inflammation response, especially in fat tissue Promotes a healthy inflammation response, especially in fat tissue Regulates gene expression Regulates gene expression Supports natural stress responses Supports natural stress responses Boosts immunity Boosts immunity Source of Quercetin: Grape skins, Red Onions, Green Tea to Tomatoes --> Flavonoids Source of Quercetin: Grape skins, Red Onions, Green Tea to Tomatoes --> Flavonoids

Study Design Study Design Subjects exercised maximally with and without ProArgi-9+ Active (Control) Subjects exercised maximally with and without ProArgi-9+ Active (Control) Lactic acid was measured pre, immediately, 15 min, and 30 min post exercise Lactic acid was measured pre, immediately, 15 min, and 30 min post exercise ProArgi-9+ Active was given 60 min before exercise in study ProArgi-9+ Active was given 60 min before exercise in study ProArgi-9+ Active HDHI Study

ProArgi-9+ Active Results

SubjectControlProArgi-9+ Active Endurance in min. 15% increase with ProArgi9+ Active

ProArgi-9+ Active Low level exercise vs. High Intensity Exercise

WE GET A D 84% of patients Screened for Vitamin D3 were deficient: 18% < 10 18% < 10 32% % % % N=1038 N=1038

WE GET A D Average replacement instituted at HDHI Average replacement instituted at HDHI 3500 units/day 3500 units/day Once target is attained( > 50 ng/dl ) Once target is attained( > 50 ng/dl ) Then maintenance dose: Then maintenance dose: units/day units/day

WE GET A D BREAST HEALTH BREAST HEALTH COLON HEALTH COLON HEALTH ANTIOXIDANT ANTIOXIDANT BONE HEALTH BONE HEALTH IMMUNE SYSTEM IMMUNE SYSTEM CARDIOVASCULAR HEALTH CARDIOVASCULAR HEALTH