Supplementary Figure 1A

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Supplementary Figure 1A Residue 22 D (Asp) E (Glu) Residue 81 I (Ile) V (Val) Residue 132 H (His) Y (Try) Residue 154 Residue 160 A (Ala)

Residue 270N Residue 270I Residue 301S Residue 301T T (Thr) N (Asp) I (Ile) Residue 270I Residue 301T L (Leu) Residue 301S S (Ser) Residue 302 G(Gly) Residue 380,383,386 K (Lys) R(Arg)

Supplementary Figure 1B Residue 68 I (Ile) V (Val) Residue 169 A (Ala) R (Arg) K (Lys) Residue 231 Residue 303 T (Thr) Residue 391 Supplementary Figure 1B

Supplementary Figure 1C Residue 140 I (Ile) T (Thr) Supplementary Figure 1C