QUATERNary Structures and Denaturing of Proteins Chapter 14.11- 14.12.

Slides:

Advertisements

Similar presentations

1 Amino Acids Proteins, and Enzymes Types of Proteins Amino Acids The Peptide Bond.

Advertisements

Tertiary Structure of Proteins The tertiary structure defines the specific overall 3-D shape of the protein Tertiary structure is based on various types.

1 Amino Acids, Proteins, and Enzymes Primary and Secondary Structure Tertiary and Quaternary Structure Protein Hydrolysis and Denaturation.

Pp 50 – 51 & Pp 15 & Proteins Proteins are polymers of amino acids Each has a unique 3D shape Amino acid sequences vary Proteins are.

Definition: Proteins are macromolecules with a backbone formed by polymerization of amino acids. Proteins carry.

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Twelfth Edition© 2015 Pearson Education, Inc Proteins: Secondary, Tertiary,

Chapter 16 Amino Acids, Proteins, and Enzymes

Pages 42 to 46.  Chemical composition  Carbon  Hydrogen  Oxygen  Nitrogen  Sulfur (sometimes)  Monomer/Building Block  Amino Acids (20 different.

Proteins. Proteins / Polypeptides The functional molecules of life.

19.6 Primary Structure The primary structure of a protein is the sequence of amino acids in the peptide chain Protein backbone Ala-Leu-Cys-Met.

Protein Structure: Tertiary and Quaternary Structure 20.7 Protein Hydrolysis and Denaturation Chapter 20 Amino Acids and Proteins.

Proteins Chapter 22. Proteins (Greek = “of first importance”) Functions: –Structure - skin, bones, hair, fingernails –Catalysis - biological catalysts.

Proteins Structures Primary Structure.

Amino Acids, Proteins, and Enzymes

Proteins Dr. Sumbul Fatma Clinical Chemistry Unit

Levels of Protein Structure Peptide/Protein Formation Peptide: small, up to 50 AA Proteins: large, several 100 AA and/or multiple peptide chains.

19.1 Proteins and Amino Acids

7.5: PROTEINS Proteins Function Structure. Function 7.5.4: State four functions of proteins, giving a named example of each. [Obj. 1] Proteins are the.

Chapter 19 Amino Acids and Proteins

Lecture 4-Kumar Protein Structure and Function 1.

STRUCTURAL ORGANIZATION

Topic 7.5 Proteins (AHL).

BRANDI AND ZAK. Secondary Structure Can fold and align them selves and the repeating pattern is called a secondary structure. Common structures are the.

Enzymes. Characteristics of Enzymes Proteins Catalysts –Speed up chemical reactions without being used up.

PROTEINS. Learning Outcomes: B4 - describe the chemical structure of proteins List functions of proteins Draw and describe the structure of an amino acid.

Chapter 14 Proteins Chemistry 20. Function of proteins Fibrinogen helps blood clotting.

Chapter 14 Proteins. Peptides and Proteins Proteins behave as zwitterions. isoelectric point, pI Proteins also have an isoelectric point, pI. ◦ At its.

Protein Structure (Foundation Block) What are proteins? Four levels of structure (primary, secondary, tertiary, quaternary) Protein folding and stability.

1 Chapter Outline 13.1 Amino Acid Structures - General structure of the aa; Groups bonded to the alpha carbon; structure of aa in water; zwitterion - Classification.

PROTEIN FUNCTIONS. PROTEIN FUNCTIONS (continued)

Proteins A protein is a compound made of small carbon compounds called AMINO ACIDS There are 20 different kinds of AMINO ACIDS.

General, Organic, and Biological Chemistry Copyright © 2010 Pearson Education, Inc Protein Hydrolysis and Denaturation Chapter 19 Amino Acids and.

Sections 14.9, 14.10, 14.11, and Hannah Nowell and Jenny Sulouff.

Chapter Proteins: Secondary, Tertiary, Quaternary, and Denaturation.

PROTEIN STRUCTURE Brianne Morgan, Adrienne Trotto, Alexis Angstadt.

Protein Recap. Protein Syllabus Draw the general amino acid structure.

SBI4U - Biochemistry Macromolecules 3 Proteins. very diverse group of molecules responsible for many vital structures and functions in living things.

Proteins  Are the most diverse biomolecules. They make up muscles, skin, hair, enzymes, hormones, hemoglobin, and antibodies.  The basic structure unit.

Protein Structure.

Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 16 Amino.

Levels of Protein Structure Peptide/Protein Formation Peptide: small, up to 50 AA Proteins: large, several 100 AA and/or multiple peptide chains.

Proteins 1 o structureamino acid sequence 2 o structure  - helix  -sheet H-bonding between C=O and N-H of backbone -- ++ some proteins only have.

WARM UP 1/29/16 1. Name the six functional groups. 2. Draw the STRUCTURAL formula for each one.

3S: Proteins Shireen Rudina. What do proteins do? Structure – Collagen in skin, keratin in hair and nails Signaling between cells Defend against disease.

Peptides. Structure and functions of proteins Department of General Chemistry Poznań University of Medical Sciences MD 2015/16.

Proteins Structures and Functions. What? A series of amino acids in a polypeptide chain Produced from the coding in the DNA of the nucleus Makes up.

Proteins Fibrous 1o structure amino acid sequence 2o structure

19.5 Protein Structure: Tertiary and Quaternary Levels

Proteins: Secondary, Tertiary, Quaternary, and Denaturation

19.6 Protein Hydrolysis and Denaturation

Structures of Proteins and Denaturation

Protein Structure.

Protein Architecture and Biological Function

Amino Acids, Proteins, and Enzymes

Protein Structure and Examples

See Page 563 Essential amino acids must be obtained from the diet.

PROTEINS and ENZYMES!.

The Chemistry of Life Proteins

Amino acids R-groups non-polar polar acidic basic proteins

Chapter 19: Proteins.

Protein Structure Chapter 14.

Amino acids R-groups non-polar polar acidic basic proteins

Proteins C, H, N, O, S 50% of the Dry Weight of Living Organisms

Proteins Fibrous 1o structure amino acid sequence 2o structure

Protein (cont.) Definition

C-Notes: Proteins General Structure

Protein Structure and Examples

Presentation transcript:

QUATERNary Structures and Denaturing of Proteins Chapter

Quaternary Structure -The highest level of protein organization, Quaternary Structure, refers to proteins with more than one polypeptide chain. -Broken up into Subunits: 1.Hemoglobin 2.Collagen 3.Integral Membrane Proteins

Hemoglobin Made up of 4 chains, called “Globins” 2 α chains of 141 amino acid residues. 2 β chains of 146 amino acid residues. Each Globin Chain encompasses an iron-containing heme unit. Conjugated Proteins- Proteins that contain non-amino acid portions. Prosthetic Group- The non-amino acid of a protein.

Hemoglobin: The Revenge Hemoglobin is not merely separated into the two aforementioned groups. As a fetus our Hemoglobin has a greater affinity for oxygen than as a born human. This is because the mother supplies the blood for the fetus. This also helps eliminate symptoms of Cell Anemia.

Collagen  A grand example of another quaternary structures in proteins.  Constituted by triple helix units called tropocollagen!  After a long time, they become insoluble.  Cross-linking allows helixes to connect and creates the stabilized formation of proteins structures.

Integral Membrane Proteins  Traverse a protein layer either partly or completely.  % of proteins are estimated to be Integral Membrane Proteins.  This allows polar proteins to remain stable in a non-polar environment.  2 Quaternary Structures: + 6 to 10 α-helices crossing the membrane + β-barrels 8, 12, 16 or 18 antiparallel sheets.

Denaturation of Proteins Denaturation- the process of the loss of a secondary, tertiary, or quaternary proteins through the use of a chemical or physical agent. Agents of Denaturation: Heat, 6m Urea, Detergents, Acids/bases, Salts, Reducing Agents, Heavy Metals, and Alcohol. Each Denaturation Agent affects a different part of the protein! The Denaturation Process is the process that happens when one boils an egg.

Collagen 2: The Sequel Reducing agents can…reduce… -S-S- bonds to form –SH groups. This is what makes your hair curly I with a straightener. Heavy Metal ions form salt bridges which denatures milk and eggs. Denaturing also sterilizes skin before injections. Denaturing is reversible if the changes are minimal.