2/25/14 109th Day of School Learning goal (7.L.2.2 & 7.L.2.3): I will be able to describe sickle cell anemia and use a Pedigree to track inheritance of such genetic disorders. Due Today: Late work Evening Assignment: FINISH Genetic Vocabulary chart

St. Baldrick’s Cancer Research Fundraiser A way you and your family can help fund research to fight childhood cancers: Donate at least $1 dollar to the Hawley Hornets team. Homeroom teachers will collect your donations until Friday. *** all donations are tax deductible *** Hawley Hornets Team Dr. Batten Shon B. Justice N. Logan Jacobi Cody Wilkins Ethan Batten-Hicks $200 from Hawley!!! $650 Total raised so far

Do Now McDougall p. C147 Read the two paragraphs from McDougall p. C147 and answer the following on the slip of paper. 1.How is having sickle cell disease detrimental to a person’s health? 1.How could having the sickle cell trait actually be beneficial? 1.Why does sickle cell anemia have the highest incidence in African- American populations?

Sickle Cell Anemia

Sickle Cell Anemia McDougall p. C Description: Sickle Cell Anemia is a recessive genetic disorder caused by a mutation that deforms the hemoglobin proteins in red blood cells leading to a sickle shape. Symptoms include intense pain, fatigue, stunted growth. Cause: Sickle cell anemia is caused by a single mutation in the hemoglobin gene on chromosome 11 resulting in a change in the hemoglobin protein. Inheritance: Sickle cell anemia is a recessive disorder. Patients who carry only one allele for the sickle cell mutation (Ss) are carriers of the sickle cell trait. Only people who inherit two mutated alleles have sickle cell anemia (ss). Incidence: SCD affects 90,000 to 100,000 Americans. SCD occurs among about 1 out of every 500 Black or African- American births. SCD occurs among about 1 out of every 36,000 Hispanic-American births. SCT occurs among about 1 in 12 Blacks or African Americans. (Source: CDC)CDC Treatment: There is no cure for sickle cell anemia however you can treat the symptoms. Pain medication, Hydroxyurea (reduces painful crisis), blood transfusions, antibiotics (to prevent infections especially in children).

Sickle Cell Anemia Pedigree Can you write a story describing this family

Sickle Cell Pedigree Create a pedigree with the following information: Both grandmother and grandfather are carriers of the sickle cell trait. They have four children – Healthy male who marries a woman with the sickle cell trait. They have a female child who is healthy Male who has sickle cell anemia (didn’t marry or have children) Male who is a sickle cell carrier (didn’t marry or have children) Female who also is a sickle cell carrier and marries a man who has sickle cell anemia They have male and female children with the sickle cell trait

Sickle Cell Pedigree Create a pedigree with the following information: Both grandmother and grandfather are carriers of the sickle cell trait. They have four children – Healthy male who marries a woman with the sickle cell trait. They have a female child who is healthy Male who has sickle cell anemia (didn’t marry or have children) Male who is a sickle cell carrier (didn’t marry or have children) Female who also is a sickle cell carrier and marries a man who has sickle cell anemia They have male and female children with the sickle cell trait

Genetics Vocabulary Flashcards due 2/28/14 Acquired Trait Acquired trait Inherited trait Sexual reproduction Heredity DNA Chromosome Gene Allele On the FRONT Definition/characteristics: A trait or characteristic that is developed or learned through life. Traits you aren’t born with. Traits GENERALLY not controlled by DNA. Examples: Walking, speaking English, dyed hair, pierced ears, Glasses, skin cancer? On the BACK Genotypes Phenotype Dominant Recessive Gregor Mendel Pea Plants Huntington’s Disease Punnett Square Monohybrid cross Homozygous (Purebred) Heterozygous (Hybrid) Mutation Genetic Disorder Sickle Cell Anemia Hemoglobin Pedigree

Genetics Vocabulary Chart – Due 2/26/14 WordDefinition & characteristics Examples Inherited traitTraits that you are born with that are passed to you through your parents genes. Eye color, hair color, widow’s peak HomozygousA trait where both alleles are identical (purebred). SS, tt, NN GenotypeGenes an organism has.Gg, SS, tt PhenotypePhysical traits that are observed or present Blue eyes, sickle cell anemia Make a genetics vocabulary word chart as a study guide for your vocabulary quiz on Friday. See some examples below. Include ALL 24 vocabulary words!

Genetics Projects – due 3/21/14 Selective Breeding vs. Genetic Modification Corn is one of the most manipulated crops. Create a Presentation or Poster comparing traditional selective breeding vs. genetic modification (GMO). Explain the two methods and then show some specific corn varieties/cultivars that were created with each method and how. Genes associated with inherited traits We learned about several common inherited human traits. Pick at least 10 traits to research and which genes control these traits. Include pictures of the traits phenotypes as part of your presentation. You may complete as a Word document or presentation. Inheritance of Eye Color Create a Powerpoint presentation about the genetics of eye color. Include information about the different types of eye color, any genes that are associated with eye color, and how eye color is inherited. In your final slide, explain how YOU inherited your eye color. Myths of Human Genetics Dr. John McDonald from the University of Delaware has written that many of the inherited traits students learn in genetics class AREN’T really inherited in a simple dominant vs. recessive pattern that is taught. Create a Powerpoint to review his arguments and compare it to what MOST genetics students learn. Meiosis Game Create a game to help students learn the steps of meiosis. Students must answer questions about chromosomes, genes, DNA, and meiosis to advance through the stages of meiosis I and meiosis II. You win when you reach the final gamete stage. Plant Genetics Grow two different species of plants and create a digital comparison of their phenotype similarities and differences (appearance, size, growth rate, etc). Then research the genetics of the two species summarizing what you find. Include the number of chromosomes and genome size Expanded Traits Survey Create YOUR OWN survey of ten inherited traits. You may use 5 of the ones we did but must include 5 new ones. Sample at least 50 people. Write up your finds as a Research Investigation Article – but with more detailed and thorough sections than we did as a class. Genetic Disorders Create a Presentation about a specific genetic disorder. You must include the following information about that disorder: description, signs/symptoms, how it’s inherited or acquired, genes affected (including the mutation if known), incidence, and treatment. GMOs in the News Farmers and scientists use GMOs to create better crops. Write a news article picking a specific GMO and discuss the process, the benefits, and risks of using that GMO History of Genetics Create a timeline about the history of genetic knowledge starting with ancient times (ex. Biblical times) through the present. You must have at least 15 descriptions along the timeline. Selective Breeding in Dogs Dog Breeders use selective breeding to improve dog breed. Create a brochure to explain the selective breeding process and use specific examples to show how breeders have gotten new dog breeds. Pedigree Analysis Create a pedigree of at least three generations using a single inherited trait. You must use a REAL family either your own or one you research. Include a Punnett square from each generation to show how that trait was inherited (3 total) Choose ONE of the following projects to do as a summative MAJOR assessment for the Genetics Unit. Do detailed, quality work to get full credit.

Evening Assignment Tonight… 1. FINISH Genetics Vocabulary chart 2. Complete late work!