Chapter 1 Lecture Outline See PowerPoint Image Slides for all figures and tables pre-inserted into PowerPoint without notes. Copyright (c) The McGraw-Hill Companies, Inc. Permission required for reproduction or display.

Anatomy and Physiology The science of our own bodies Human structure and function, the biology of the human body Foundation for advanced study in health care, exercise physiology, pathology and other fields related to health and fitness

Anatomy - The Study of Form Observation of surface structure Cadaver dissection cutting and separation of organs to study their relationships Comparative anatomy study of more than one species to analyze evolutionary trends

Dissection- cutting and separation of tissues to reveal their relationships Anatomy and dissection both mean “cutting apart”

Anatomy - The Study of Form Physical examination Palpation: feeling a structure w/ the hands Auscultation: listening to natural sounds Percussion: examiner taps the body Gross anatomy visible with naked eye Histology examination of cells with microscope

Physiology - The Study of Function Study of bodily functions using methods of experimental science Comparative physiology study of different species Basis for the development of new drugs and medical procedures

Scientific Knowledge Inductive Method: process of making numerous observations until one feels confident in drawing generalizations from them (anatomy) Hypothetico-deductive Method: start with hypothesis, make deduction (if, then prediction), experiment, results either support or do not support hypothesis (physiology)

Scientific Method

Hypothesis Consistent with what is already known Capable of being tested and possibly falsified by evidence Falsifiable means that if we claim something is scientifically true, we must be able to specify what evidence it would take to prove it wrong If nothing could prove it wrong, it is not scientific

Is it better to treat seizures immediately or wait until epilepsy is well established? Early treatment of seizures will result in better seizure control than the same treatment when administered later in the development of epilepsy Collect data: animal model- produce rats with audiogenic seizures. Treat some with anti seizure meds immediately after first seizure (experimental group 1) Treat other group later after pattern of seizures is well established (experimental group 2) Compare both to another untreated group (control) Why do we need a control group?

Experimental Design Sample Size: adequate sample size controls for chance events and individual variations in response and enables us to place more confidence in the outcome Controls: Biomedical experiments require comparison between treated and untreated individuals so that we can judge whether the treatment has any effect Control group: subjects are as much like the treatment group as possible except with respect to the variable being tested

Psychosomatic effects: effects of subject’s state of mind on physiology, must control for this Give control group a placebo (substance with no physiological effect) Neither group must know which tablet it is getting

Experimenter bias Double-blind method: neither the subject to whom a treatment is given nor the person giving it and recording the results knows whether that subject is receiving the experimental treatment or placebo

Statistical testing: How great a difference must there be between experimental and control groups before we feel confident that it was due to treatment and not random variation? Expressed as probability Peer Review: when scientist applies for research funds or submits work for publication work is subject to peer review- a critical evaluation by other experts in that field. At every stage from planning to postpublication, scientists subject to scrutiny by their colleauges. Mechanism to ensure honesty, objectivity, and quality in science.

What makes something alive?

Characteristics of Life High level of Organization Made of Cells Metabolism Responsiveness Movement Growth Development Reproduction

Hierarchy of complexity

Anatomical Variation No 2 humans are exactly alike variable number of organs variation in organ locations (situs inversus, dextrocardia, situs perversus)

Organ Systems

Organ Systems

stable internal conditions regardless of external conditions Homeostasis = body’s ability to detect change, activate mechanisms that oppose it, and thereby maintain stable internal conditions Claude Bernard (1813-78) stable internal conditions regardless of external conditions Homeostasis Walter Cannon (1871-1945) coined the term fluctuates within limited range around a set point Loss causes illness or death

Feedback Mechanisms Receptor = senses change Afferent Pathway Control Center Efferent Pathway Effector = structures that restore homeostasis

Negative Feedback Loop Body senses a change and activates mechanisms to reverse it

Negative Feedback, Set Point Room temperature does not stay at set point of 68 degrees -- it only averages 68 degrees

Human Thermoregulation Brain senses change in blood temperature if overheating, vessels dilate in the skin and sweating begins if too cold, vasoconstriction in the skin and shivering begins

Control of Blood Pressure Circulatory stretch receptors detect a rise in BP Cardiac center in brainstem sends out nerve signals Heart slowed and BP lowered

Positive Feedback Loops Self-amplifying change leads to change in the same direction Normal way of producing rapid changes occurs with childbirth, blood clotting, protein digestion, and generation of nerve signals

Review of Major Themes Cell theory Homeostasis Evolution activity of cells determine structure and function Homeostasis maintaining stable internal conditions Evolution our body evolved by natural selection Hierarchy of structure levels of complexity Unity of form and function physiology is inseparable from anatomy