International Clinical Research Center (ICRC) Brno Presentation for Mrs Sian MacLeod and Team of British Chamber of Commerce Presentation for Mrs Sian MacLeod and Team of British Chamber of Commerce

International Research Centers ISS International Space Station CERN(Switzerland) European Organization for Nuclear Research ICRC Brno (Czech Republic) International Clinical Research Center Brno ITER (France 2014) International Thermonuclear Experimental Reactor ISS International Space Station CERN(Switzerland) European Organization for Nuclear Research ICRC Brno (Czech Republic) International Clinical Research Center Brno ITER (France 2014) International Thermonuclear Experimental Reactor

Combination of: Next-generation clinical research base State-of-the-art clinical center for treatment of cardiovascular and CNS diseases International educational center Technological cluster Integral part of St. Anne’s University Hospital PLATFORM FOR MULTIDISCIPLINARY INTERNATIONAL COLLABORATION integrating clinical research, clinical care, medical education and TT Combination of: Next-generation clinical research base State-of-the-art clinical center for treatment of cardiovascular and CNS diseases International educational center Technological cluster Integral part of St. Anne’s University Hospital PLATFORM FOR MULTIDISCIPLINARY INTERNATIONAL COLLABORATION integrating clinical research, clinical care, medical education and TT ICRC BRNO

ICRC Novel concept of clinical research Proactive international scientific networking Flexible laboratory track system Dynamic Research Team Proactive international scientific networking Flexible laboratory track system Dynamic Research Team International Space Station (ISS)

ICRC Clinical Research – Major Goals Early detection of cardiovascular and neurological diseases Identification of novel risk factors of CV and neurologic disorders Development of novel diagnostic and therapeutic technologies for cardiovascular and CNS disease Individualized medicine Early detection of cardiovascular and neurological diseases Identification of novel risk factors of CV and neurologic disorders Development of novel diagnostic and therapeutic technologies for cardiovascular and CNS disease Individualized medicine

ICRC in Numbers Budget of USD 220 million approved by E.U. and Government of the Czech Republic 450 Employees Ongoing construction Budget of USD 220 million approved by E.U. and Government of the Czech Republic 450 Employees Ongoing construction

Ongoing ICRC Construction ICRC will became fully operational in October 2012

ICRC Brno Science Without Borders

Examples of Mayo – EU Partners – ICRC Collaborative Research Projects Development of Mechanical and Biological Artificial Heart

Brno Artificial Heart Project Prototypes TNS Brno II-VIII Longest EU survival in cows – 314 days

Mayo-Brno Artificial Heart Program Mechanical Approach Development of the next generation with physiological regulatory feedback system Development of original fully implantable Mini- Artificial Heart Heart Mate II

ICRC Ongoing Collaboration with Scientific Teams from U.K. University of Dundee University College London University of Dundee University College London

Xenotransplant Engineering Development of Biological Artifical Heart Cardiac Tissue Engineering Development of novel type biological heart valves PI: Prof. Christopher McGregor (University College London) Xenotransplant Engineering Development of Biological Artifical Heart Cardiac Tissue Engineering Development of novel type biological heart valves PI: Prof. Christopher McGregor (University College London) University College London - Mayo-Brno Artificial Heart Program Biological Approach

Dundee Development of Operating Theatre of the Future

Good Luck with the Games! Oxford – Cambridge Rowing Race