TBLI and HIV

 30% of People infected with HIV/AIDS and have latent TB will eventually get active TB (5 -10% /year).In HIV negative 5-10 % during their life.

It is known that treatment of latent TB infection(LTBI) or TB preventive therapy, helps to prevent progression to active disease

 Isoniazid prevention therapy (IPT ) 6-12 months

PREVALENCE OF ACTIVE TB IN PEOPLE WITH HIV WHO HAVE LATENT TB AND TREATED WITH INH FOR 6 MONTHS FROM S.mansuri M.HajiabdolbaghiM.Hasibi

Inclusion criteria HIV positive who have been treated with INH for 6 months and fallowed up for 1 year after Exclusion criteria Sputum AFB positive during INH prophylaxis CxR or CT compatible with TB Pathology compatible with TB LTBI prophylaxis with other drug except INH

Results

Table - 1 TST result NumbersPercentTST Positive Negative TST was done TST was not done Sum

In this study TST was done in67.2% of all HIV patients in our center. This rate in other studies was between 50 %- 79%

TST number Positive number Percent 1128 (M.haji) NA (mohraz) NA25% NA(alavi)NA54.5 NA (Alaee) NA88% NA(Shokoohi)NA39.4

In other studies prevalence of TBLI in HIV positive from 25% to 46% is reported.

TST Prophylaxis numberpercent INH prophylaxis No INH prophylaxis 6.93 PZA,RIF prophylaxis Sum Sum

 In other studies( WHO.USA. Brasilia) 25%,46% 59.8% HIV positive patient with LTB have received IPT

Mean follow up period was 3.5 ( 1.5± 3.5 )

PPD+ PPD- INH≥6m INH-INH<6m Cases Number TB cases TB% /49 TB cases in PPD+ and PPD -

Variable Age 57/ 8± 39.75) Sex M 264 (85%) F46 (15%) CD ART yes 218(70/3%) yes 218(70/3%) No 92 (29/7%)

76% of our cases had compliance to prophylaxis 76% of our cases had compliance to prophylaxis

Mean period of time between IPT to treatment of TB in 6 TB cases was 24.7 months

 1672 PPD - No PPD PPD INH+397INH Z+R6

134 TB cases PPD No PPD No IPT PPD+ INH <6 mo Complete IPT 62.6

TB before HIV diagnosis TB after HIV diagnosis TB,HIV same time 3828,35 ART before TB diagnosis ART after TB diagnosis TB cases

TB after ARV