Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes in Descending Thoracic Abdominal Aortic Aneurysm Repair Cardiothoracic and Vascular.

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Impact of Autologous Platelet Rich Plasma Transfusion On Clinical Outcomes in Descending Thoracic Abdominal Aortic Aneurysm Repair Cardiothoracic and Vascular Anesthesia Department of Anesthesiology The University of Texas Medical School at Houston S. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S. Panthayi, MD, H. Safi, MD, R. Sheinbaum, MD

Autologous Platelet Rich Plasma Harvesting Platelet Rich Plasma WB aPRP RBC Collected by harvesting ml/kg whole blood prior to CPB Fractionating off the PRP component. The goal was a yield of ml/kg of aPRP.

 aPRP was used to reestablish hemostasis and significantly reduce intra-operative transfusions  Investigate the effect of aPRP transfusion on the clinical outcome of patients undergoing TAAA repair. Purpose

 Retrospectively reviewed 535 cases of TAAA repair  Ages 18-80,  From Feb to July  182 patients received aPRP harvest and 353 patients did not. Materials and Methods

Patient Demographics Demographics and surgical characteristic between two groups were similar.

Intra-Operative Blood Transfusion Intra-Operative blood transfusions were significantly reduced in the aPRP cohort.

Intra-Operative Blood Transfusion

Results  In the PRP group 24/182 (13.2%) received no transfusions 134/182(73.6%) received no platelet transfusion 69/182(37.9%) required 4 or less units of PRBC transfusion

Morbidity

Time To Extubation The aPRP group also required reduced ventilator time and were extubated earlier

Conclusions  Use of PRP in thoracic and thoracoabdominal aortic aneurysm repair resulted in reduced blood product utilization translating into improved morbidity and mortality.  Prospective randomized studies are required.