Tissue Regenration by local administration of autologeus conditiond Concentrate of Thrombocytes in Orthopedics and Sporttraumatology

Thrombocytes concentrates PRP Platelet-rich Plasma Platelet-rich PlasmaP-LRP Platelate leucocyt rich plasma Platelate leucocyt rich plasmaACP Autologeus Conditiond plasma Autologeus Conditiond plasma

Thrombocyte with alpha granules, Lysomoe and Delta granules (Dense Bodies)

Penetration from Thrombin into Thrombocyte causes releasing of alpha granules and lysosome to infiltration in wound of fracture

Growth Factors GF Mechanismus of action PDGF PDGF Platelet devired Growth Factor Platelet devired Growth Factor TGF – ß TGF – ß Transforming Growth Factor Beta Transforming Growth Factor Beta VFGF VFGF Vascular Endothellial Growth Factor Vascular Endothellial Growth Factor EGF EGF Epidermal Growth Factor Epidermal Growth Factor Recurit smoth muscle cell Remodels extracellular matrix Affectes Angiogensis and permealbilty Promotes angiogensis and epithelial cells

Endothelial cells migrate as reparing cells to traumatized area

Vascular endothelial growth factor (VEGF) stimulates diveloping of new blood vessels

Platelet drived factor (PDFG-AB) intensifieds mitogenisis and angiogenesis activates macrophages, stemcells and recriute smoth muscle and connective tissue celles.

Transforming Growth Factors Beta (TGF) promotes extraecellular matrix and musculoskletal production

Traumatic rupture of anterior cruciate ligament

Regeneration 3 months after application of ACP

Traumatic rupture of the ligamentum patella

Surgical reconstruction and application of ACP

Rupture of the medial Mensikus

fresh traumatic rupture of the medial meniscus

Traumatic rupture of the medial meniscus surgical suture and aplication of ACP

Achillodynie

MRI of Achillestendon

2 weeks afterwards of ACP application

Technique of autologous conditioned plasma

Thank you so much for your attention Prof.Dr.med.Y.M-Goudarzi