Cyclic Vomiting Syndrome LT Greg Gorman. Features Diagnosed 3-6 times a year in tertiary hospitals. 20-30 times a year in Germany after WW2 Boys and girls.

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Presentation transcript:

Cyclic Vomiting Syndrome LT Greg Gorman

Features Diagnosed 3-6 times a year in tertiary hospitals times a year in Germany after WW2 Boys and girls equally

Age of Onset

Episodes Episodes are similar 85% have uniform length episodes 1-70 episodes per year (avg. 12) 50% have regular cycle

Course in 5 y/o girl In hours; green boxes are episodes

Course in 12 y/o girl /2 11 wks14 wks 12 wks 10.6 wks In hours; green boxes are episodes 12 th birthday 1 st day of school Parents out of town Parents went to Dineyland without her

Course in 8 y/o girl In hours; green boxes are episodes

Course in 14 y/o boy In hours; green boxes are episodes

Duration of Episodes Fleisher, 1993

Timing of Episodes Charateristic timing in 76 % Usually upon awakening or middle of night Fleisher JPGN ‘93

Associated Symptoms Epigastric pain Nausea Saliva holding Loose stools (30 %) Headache (27 %) Fever (23 %) Occasional hypertension, tachycardia

Associated Symptoms Willingness to drink water “I drink the water because sometimes vomiting helps to relieve the nausea and, as far as I know I’m going to vomit anyway, it is far less unpleasant to bring up a dilute solution than to vomit concentrated hydrochloric acid…”

Associated Symptoms Triggers (75 %) Parental conflict (most common) Non-noxious excitement (birthdays etc) URIs Others: Menstruation, hot weather, exhaustion, motion sickness, specific foods, asthma attacks

Family History IBS (67 %) (2-6x normal prevalence) Migraine (11%) Motion Sickness (46%) Type A Personality (76%) Epilepsy (6%) (10x normal prevalence)

Course Over half symptom free 1 yr later Others last decades ? End at puberty

Pathogenesis Migraine equivalent Fits pattern and family history Eipileptic equivalent Case report of 5 seizure patients with CVS pattern

Differential Diagnosis Brain Stem Glioma Obstructive Uropathy Others

Management Anti-emetics Induction of sleep Resolution with consultation alone Psychosocial support