A computational model for the formation of lamin-B mitotic spindle envelope and matrix by Changji Shi, Wilbur E. Channels, Yixian Zheng, and Pablo A. Iglesias.

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Presentation transcript:

A computational model for the formation of lamin-B mitotic spindle envelope and matrix by Changji Shi, Wilbur E. Channels, Yixian Zheng, and Pablo A. Iglesias Interface Focus Volume 4(3): June 6, 2014 ©2014 by The Royal Society

Reactions included in the model. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

Geometric description of the model. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

MT polymerization gives rise to two asters which are pushed away by the MT-based motors. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

The complete model shows that a lamin shell is formed around the MT spindle region. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

Effect of RanGTP on the production of the spindle. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

Comparison of two putative networks for lamin matrix formation. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

Sensitivity analysis for various model parameters. Changji Shi et al. Interface Focus 2014;4: ©2014 by The Royal Society

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